The Effect of Exposure to Alcohol During Prenatal Development
[2023-03-06 12:39:03]
Exposure to alcohol during prenatal development is one of the leading causes of preventable birth defects and psychiatric disorders (Bower, Szajer, Mattson, Riley, & Murphy, 2013; Nuñez, Roussotte, & Sowell, 2011; Sowell et al, 2008a). Fetal Alcohol Syndrome (FAS), a form of more serious PAE, affects 2 to 7 out of every 1,000 people in the United States (May et al., Simmons, Thomas, Levy & Riley, 2010 Quote). The term fetal alcohol spectrum disorder (FASD) stands for individuals with different levels of PAE. It is estimated that one out of every 100 people have some form of FASD, as Sampson et al. (As Simmons et al. Cited in 2010). Many studies are being conducted due to the high prevalence of the population.
Alcohol has been shown to alter normal brain development by interfering with normal cellular processes involved in cell division and gene expression. Guerri and Renau-Piqueras (1997) explain that alcohol influences cell division by inhibiting cytoskeletal activity. This increases the G 0 and G 1 phases of the cell, which reduces the number of mitotic cells undergoing cell division. Later work by Anthony, Zhou, Ogawa, Goodlett, and Ruiz (2008) found similar findings of mitotic cell depletion, but by inducing apoptosis. They examined the effect of PAE on cell cycle G1 and S phase using mouse dorsal root ganglion stem cells. Except for the control group, cell cultures were exposed to 200 mg / dl or 400 mg / dl alcohol. These investigators have shown that alcohol exposure increases the levels of cyclin D1, cyclin D2 and E2F1 and that each cell plays an important role in the regulation of G1 and S phase of the cell cycle and subsequent cell division I found out. Overexpression of these proteins leads to regulation of the cell cycle, changes in DNA synthesis, increased DNA fragmentation, and ultimately apoptosis. This confirms their finding that it reduces the number of cells in culture exposed to alcohol.
In addition, alcohol was found to affect DNA replication by altering the DNA methylation process. DNA methylation (5 mC)
Alcohol exposure before birth may harm the developing fetus and is a preventable major cause of birth defects and mental and neurodevelopmental disorders. In 1973, fetal alcohol syndrome was first described as a group of specific birth defects caused by intrauterine alcohol exposure. Research has shown clearly that there is a possibility that prenatal alcohol exposure may cause a wide range of harmful developmental effects. Fetal alcohol spectrum disorder (FASD) is a general term that encompasses a series of adverse reactions associated with prenatal alcohol exposure. The diagnostic criteria for fetal alcohol syndrome are specific and comprehensive efforts are being made to establish standards for diagnosing other FASDs. Based on the following assumptions, based on research, evidence-based FASD experts, public education, broad precautions, and recommended treatment were born.
FASD is a general term for the range of health effects caused by prenatal alcohol exposure. People suffering from FASD may develop organ damage including growth disorders, facial anomalies, and brain damage. The brain impact of prenatal alcohol exposure can cause a range of neurobiological defects that lead to physical, cognitive, behavioral, and social issues throughout life. George F. Koob, director of NIAAA, says, "The prevalence of FASD in the United States is estimated to be complicated due to the task of identifying pre-natal exposed children.