Perfection Is Skin Deep: Everyone Has Flawed Genes
[2024-03-06 22:41:11]
Researchers discovered that ordinary healthy people have a surprisingly large number of mutations in their genes.
It is well known that all people's DNA is defective, but in most cases these defects are harmless. However, it is not clear how much error is lurking in someone's genes.
Chris Tyler-Smith of the Wellcome Trust Sanger Institute in Cambridge, UK says: "It is estimated that very few have reached over 100 serious disease-related mutations."
However, Taylor - Smith and his colleagues want to obtain more accurate and direct estimates. Therefore, they analyzed the DNA of 179 patients from the United States, Japan, China, and Nigeria who autonomously decoded their genetic blueprint through 1,000 genome projects. Researchers reported surprises in the paper published at the American Journal of Human Genetics now.
Taylor Smith said: "We have found many harmful and known pathogenic mutations."
According to their analysis there are about 400 defects in the genes of the general population, including at least one pair of disease related defects.
Strangely, a person who has never studied DNA is sick. They all look very happy and healthy
"In some cases, another copy of that gene or a similar gene may take over," Tyler-Smith said.
In this study, one out of ten had a genetic mutation that should cause disease, but it is not so. Taylor Smith has a theory
"Somewhat surprisingly, people should walk around and look healthy, but we see a known pathogenic mutation in their genome," he said. "But the answer is that they tend to be mild and often late, as well as heart disease, the risk of cancer increases."
Other researchers praise this research for scientists trying to understand gene mutations and true understanding of disease.
Robert Green, a geneticist at Harvard University, said, "I am very surprised by the total number and frequency of the people they found."
However, Mr Green and others said that this research is also causing serious concern. It shows how large gene sequencing can find mutations that might frighten people, and we find that this is not a good reason.
"Important medicine to bring home here - a medicine that needs to be strengthened - When we enter the era of genomic medicine, it is not that you are suffering from a disease's mutation only. say
So, as James Evans of North Carolina University said, the new research shows that we all need to get used to the idea that no one is perfect. Far away
"We are all mutants," Evans said. "The good news is that most of these mutations do not cause disease, and we seem to have various redundancies and backup mechanisms to cope with this situation."
Most of the genes we got from our parents are replicas of our parents. But sometimes the gene is not a complete copy. Changes in genes are called mutations, and everyone has several. Some mutations are superior to the original mutation, many of them are not different. Several mutations can cause problems. The condition caused by mutation of one or more genes is called genetic disease. There is a rare group of diseases caused by a single genetic mutation. These are called monogenic diseases. However, the most common diseases are caused by genetic change, lifestyle choice and environmental combination.
Hereditary diseases affect mainly the skin and its appendages. These are caused by single gene mutations. Hereditary skin diseases are also known as hereditary skin diseases. There are nearly 44 skin diseases, some of which are skin cancer, lupus, acne, psoriasis, urticaria, convulsions, convulsions, and hyperhidrosis. Melanoma and skin diseases, psoriasis and rosacea open access, dermatitis, pigmentation abnormality, Soviet genetics, skin pharmacology and physiology, advances in skin biology, skin research, skin research and technology, skin care, international skin care communication, skin Progress and Wound Treatment