Pathophysiology of Functional Gastrointestinal Disorders: A Holistic Overview.
[2023-04-25 10:58:53]
Australia, Queensland State Uo Round Gabba, Alexandra Princess Hospital, Gastroenterology and Liver Internal Medicine
Queensland University School of Medicine, Health and Behavior Science Division, Queensland, Queensland, Australia
Background and summary: Traditionally, functional gastrointestinal disorder (FGID), including functional dyspepsia or irritable bowel syndrome (IBS), is caused by structural or biochemical (FGID), which causes these symptoms more or less by specific symptoms and absence I have an abnormality. Define it. This concept is now considered to be outdated; many patients may find structural or biochemical abnormalities that explain or cause symptoms if properly tested. Another characteristic of FGID is a very common psychiatric disorder such as depression and anxiety. Emotional disorder means "causing" gastrointestinal symptoms. In fact, epidemiological data now provide strong evidence that gastrointestinal (GI) symptoms first appear in a subgroup of cases, mood disorders occur late, and in the other case vice versa. Possible mechanisms of intestinal-brain dysfunction have been identified and systemic minimal inflammation is the causative factor in at least some subjects. Other mechanisms that play a role in FGID include chronic infections, intestinal flora, low malignant mucosal inflammation including eosinophilia, systemic immune activation, changes in intestinal permeability, diarrheas, mainly IBS , Changes in bile salt metabolism, abnormal metabolism and serum containing genetic factors All these factors may be regulated by environmental factors such as diet. IMPORTANT MESSAGE: While many factors may be related to certain symptoms (such as pain and diarrhea), it is clear that patient classification based on symptoms does not allow targeted therapy for specific pathophysiology
Pathophysiology of Functional Gastrointestinal Disease: Outline a, bac Gerald Holtmann Ayesha Department of Gastroenterology, Shar Mark Morrison Department of Gastroenterology, Princess Alexander Hospital, Woolen Gabba, Queensland State, Australia; University of Queensland Medical School, Behavioral Sciences Diamantina Institute, University of Queensland, Queensland, Queensland, Australia
The relevance, diagnosis and natural history of functional gastrointestinal disorders are less related to the basic pathophysiological mechanism. Provocative research such as those by Aggarwal et al are welcome. In order to cope with the influence of Schuffler MD, Rohrmann CA, Chaffee RG, Brand DL, Delaney JH, Young JH more mechanism studies were conducted on patients with functional gastrointestinal disorders. Report of 27 cases of chronic intestinal pseudo-obstruction and literature review Medicine 1981; 65: 1331-1358. Koch TR, Kearney JA, Go L, Go VLOW. Idiopathic chronic constipation is associated with a reduction in colonic vasoactive intestinal peptide. Gastroenterology 1988; 94: 300-310. Murray J, Du C, Ledlow A, Bates JN, Conklin JL. Nonadrenergic noncholinergic reaction medium in nitric oxide rat esophageal muscle Am J Physiol 1991; 261: G 401 - G 406
The most common form of functional gastrointestinal dysfunction is irritable bowel syndrome. Functional constipation and chronic functional abdominal pain are other intestinal functional disorders with physiological causes but without an identifiable structural, chemical or infectious state. Part of the area can be visualized with camera. Endoscopic examination when examining upper gastrointestinal tract, colonoscopy examination or sigmoidoscopy examination when examining the lower digestive tract is called. Capsule endoscopy is the place to swallow capsules containing the camera to inspect the tube. Biopsy can also be carried out during the examination
Functional gastrointestinal disorders, a group of symptoms characterized by chronic or recurrent symptoms associated with any part of the gastrointestinal tract. A functional state refers to an abnormal function of an organ,