What is Paget's Disease?

Paget's disease (PD), also known as osteoarthritis, is thought to be a disorder of bone metabolism. It can be explained as an accelerated and unorganized bone remodeling focal disease that affects multiple bones in the body and may result in progressive hypertrophy and bone and joint deformity. 8% for people over 50%.% Will not wait until 2 is more common. Pathological PD is explained by restricted, unbalanced, uncontrolled bone resorption of osteoclasts.

In 1877, Sir James Paget described the local bone disease first known as Paget's disease. Paget's disease is a metabolic bone disease characterized by excessive bone resorption and formation by activated osteoclasts. Skeletal Paget's disease usually occurs in people over 40 years of age and mainly affects the axis bone. Approximately 5% of patients develop symptoms that require treatment, but the most common symptom is deformation of bone pain, swelling, painful areas. Other signs of this disease include increased susceptibility to fractures, hearing loss, and neurological complications. PDB is the second most common metabolic bone disease after osteoporosis. This is more common in western countries; in contrast, it is extremely rare in most parts of China and sub-Saharan Africa.

Osteoarthritis is a common bone disease that is usually familial. Based on knowledge of the Pageu disease demographics and the existence of Paget's disease among multiple families, Grauer et al. Suggested that "genetic, infectious or environmental factors play an important role in their etiology" ing. Mutation membrane 1 mutation (SQSTM 1) previously suggested by Hocking et al. Has been shown to be a major cause of familial and sporadic Paget 's disease. Three distinct mutations affecting the ubiquitin binding domain were identified, the most important of which was in locus p392L. Sequestosome 1 encodes a component of the RANK-NFκB signaling pathway (Hocking et al). Members of the TNF receptor family RANK are receptor activators of NFκB ligands and are involved in osteoclast differentiation. Kurihara and colleagues (2007) suggest that Isolated Membrane Cell 1 (p62) gene mutation alone is not sufficient to induce Paget's disease