Chicago (Reuters) - As an important step towards the creation of artificial life, American researchers have developed creatures that combine natural and artificial DNA to create completely new synthetic proteins.
This research, published in Nature magazine, brings scientists closer to the development of custom designed proteins in laboratories.
A previous study by Chemistry Biologist Floyd Romsberg of Scripps Research Institute in La Jolla, California suggests that it is possible to extend the genetic characters of natural DNA beyond the current four letters: adenine (A), cytosine (C), guanine (G), thymine (T)
In 2014, Romesberg et al created an E. coli strain containing two unnatural letters X and Y.
In a modern study, the Romesberg team showed that this partially synthesized E. coli form can obtain instructions for making new proteins from the genetic alphabet of this hybrid.
"It is the first time in history that a cell translated proteins using proteins other than G, C, A, T," says Robsberg.
In a phone interview, he said that although the actual change in living things is small, this feat is very important. "It was the first time in history that we changed our lives."
This is the goal that Robertsberg has been working on for the past 20 years. However, creating a new lifestyle is not important. Romesberg is interested in using this extended genetic alphabet to create new proteins that can be used to treat diseases.
In 2014, he founded a company called Synthorx Inc. And it is working on new protein therapy.
"Many proteins that we would like to use as pharmaceuticals are quickly removed in the kidneys," says Robsberg. The new system will allow scientists to adhere lipid molecules to drugs to make them longer in the body
Robertsberg noticed that the production of semisynthetic organisms may cause concern about mixed organisms spreading outside the laboratory but the systems they use are unlikely to escape
For example, in natural DNA, base pairs are attracted to each other by the bonding of hydrogen atoms. Romesberg X and Y bases are fascinated by a totally different process and therefore do not accidentally bind to natural bases.
In addition, semi-synthetic creatures can not live outside the laboratory because cells can not create their own X and Y unless specific chemicals are added.
Some scientists are working to assemble and design various life blocks to achieve specific goals, such as manufacturing new chemicals and pharmaceuticals. Other research groups are developing exotic microorganisms to gain insight as to which genes are essential for the presence and make estimates of the minimum number of genes necessary to make the organism work. In 1970, he and a group of researchers successfully developed the first custom designed artificial genes and methods to predict the invention of the technology to amplify the polymerase chain reaction (PCR) process - DNA . Simply put, it is a Xerox machine for synthetic biology.
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