The Use of Proton Pump Inhibitors

Studies have shown that the number of proton pump inhibitors (PPI) has been exceeded during hospitalization and subsequent discharge from hospital. Published research showed that it is possible to save a lot of money on PPI prescriptions if several clinical guidelines are used nationwide. In addition to costs, there is the danger of devastating side effects that continue to be used. More clear reasons are needed to manage and extend the PPI.

From the first case report of hypomagnesemia in 2006 related to the use of proton pump inhibitor (PPI), (1) several similar cases were reported in science and academic journals. From 2006 to 2010, at least 8 additional reports (2 to 9) have been published, all of which explain the symptoms of hypomagnesemia in chronic PPI-exposed patients. From all these information, you can check the relationship between regular use of PPI and low serum magnesium value.

Pantoprazole is a proton pump inhibitor that inhibits gastric acid secretion by blocking proton pump or H + K + ATPase of gastric wall cells. Pantoprazole was synthesized in 1987 and was introduced in 1994 after development and clinical trials. The development of lead compound thymoprazole and the discovery of H + K + ATPase as a target are two of the two most important findings leading to the production of a new class of proton pump inhibitors. This review will explain the discovery and development stages of pantoprazole.

Proton pump inhibitors are the most effective medicine for individuals who frequently experience acidity. As its name implies, proton pump inhibitors inhibit acid production by interfering with the proton pump mechanism. When production is disturbed, it gives time to the damaged tissue of the stomach and esophagus. In a mild phase, antibiotics are prescribed for inhibitors as mucosal infections are usually associated with mild and severe cases.

Do long-term use of proton pump inhibitors know that your body may influence how to absorb essential nutrients, you know that this is often the case with nutritional deficiencies and fractures, dementia and gastrointestinal infections Do you know that it will lead to more serious side effects? The role of the proton pump inhibitor is to prevent the production of acid in the stomach, thereby raising the pH of the stomach. A sustained increase in gastric pH caused by conventional use of proton pump inhibitors has been shown to reduce the absorption of calcium, magnesium, iron and vitamin B 12. It also shows that colonization of pathogenic bacteria is promoted and opportunistic infections occur throughout the gastrointestinal tract.