The Prevention and Treatment of Missing Data in Clinical Trials

Randomized clinical trials are the primary tool for evaluating new medical interventions. By randomization, a fair comparison was made between the treatment group and the control group, balancing the distribution of known and unknown factors in the participants. Unfortunately, these studies often lack a significant percentage of data. This missing data reduces the benefits provided by randomization and introduces a potential bias in the comparison of treatment groups.

Data missing may occur for a variety of reasons, such as participants not being able to meet the assessment schedule or having no motivation. In some studies, some or all of the data collection was discontinued when participants ceased research treatment. Guidelines for the design and implementation of existing clinical trials and analysis of the resulting data only provide limited advice on how to handle missing data. Therefore, data analysis methods that contain considerable missing values ​​tend to be temporary and fluctuate.

Prevention and treatment of missing data in clinical trials concluded that more fundamental design and analysis methods may be required and adopted if there is no missing data. In this approach, we need to pay attention to two important factors: (1) careful design and action to limit the amount and impact of missing data, and (2) analysis of all random participant information Utilization of Nature In addition to the top priority recommendations, this book provides more detailed recommendations on the technology for testing clinical trials and testing data analysis.

Clinical trials include clinical trials designed to test the safety and efficacy of human intervention. Cautious clinical trials of treatment, prevention, medical devices and other interventions are conducted in the fastest, safest and best way to determine if they are suitable for cancer, HIV / AIDS, asthma and many other diseases It is considered to be. In the treatment trials, experimental treatment, combination of new drugs, or new surgical procedures or radiotherapy is tested. In the prevention test, we investigate changes in drugs, vaccines, vitamins, lifestyle habits and see if we can prevent the recurrence of diseases and diseases. Clinical trials have ethical problems. Some researchers are asked to accept burdens and risks in order to acquire useful knowledge for others.

Clinical trials are part of clinical research and are the core of all the progress of medicine. In clinical trials, new methods for preventing, discovering, and treating diseases and diseases are being studied. Treatment is a novel way to use new treatments, techniques, drugs or drug combinations, or existing treatments. Although individual participants may benefit from participating in clinical trials, participants believe that the primary purpose of clinical trials is to acquire new scientific knowledge, and in the future other people better support It is to be able to do.

Clinical trials and your clinical trial are part of clinical research and are the core of all medical progress. In clinical trials, new methods to prevent, detect and treat diseases are being studied. Treatment is a new way to use new drugs or combination of new drugs, new surgery or equipment, or existing treatment. All clinical trials have special requirements for matching with potential subjects' research, such as age ranges and other acceptable conditions / drugs. For more information on participation in clinical trials, please visit www.nih.gov / health / clinicaltrials / index.htm and use search terms such as "senile depression" or "depression and elderly people".