The Physiological Effects of Cocaine in the Neurosystem

Cocaine abuse and dependence in 2008 affected 4 million Americans (Volkow, 2010). Cocaine is known to be addictive (Letchworth et al., 2001). Therapeutic and pharmaceutical technologies used to alleviate drug action and drug seeking behaviors have become increasingly prevalent in the scientific community. In general, the affected area is determined during or after cocaine use, and physiological study of cocaine use is carried out subsequently. For cocaine use epidemics and the quality of rehabilitation that medication can provide, research must be conducted to determine drug discovery and recurrence.

Resistance to cocaine and resistance to physiological dependence of high dose cocaine may occur. With regard to withdrawal syndrome, as the stimulating CNS effect of cocaine subsides, the user experiences depression, anxiety, prolonged sleepiness, boredom, reduced motivation, and a strong desire for the drug. More powerful is the development of psychological dependence. Because cocaine has strong reinforcement characteristics and therefore recurs. Inhibitors lower the neuronal activity of the central nervous system, resulting in inhibition of behavior, reduction of anxiety, sedation, enhancement of sleep. Medicines in this group include barbiturates, benzodiazepines, some inhalable inhalants, and alcohol. Many of these drugs act on the GABA receptor complex and may be abused, abused and dependent.

Psychologically, the use of chronic cocaine is contrary to the initial effect. These influences include not being able to engage in paranoia, confusion, sexual activity. Long-term use of cocaine may also have an acute harmful physiological effect on the respiratory system, the cardiovascular system and the central nervous system. Chronic cocaine use can also cause hospital emergency rooms, psychiatric disorders due to chest pain or palpitations, changes from mental status to suicidal ideation, as well as neurological problems including epilepsy and delirium.

Cocaine is a powerful nervous system stimulant. The effect lasts from 15 to 30 minutes to 1 hour. The duration of cocaine's effect depends on the dose and route of administration. Cocaine may be in the form of a bitter tasting white powder. Inhalation or injection may cause numbness. Pyrolysis cocaine is an inhalable cocaine made by treating cocaine with sodium bicarbonate (sodium bicarbonate) and water to make a small "rock". Cracked cocaine is called "crack"