I have heard that such laughter is the best medicine. In an article that discussed the results of studies on releasing chemical substances in the brain that are well perceived, the authors wrote as follows. At the time, the pain threshold has not changed, and often these results are best explained by the action of endorphin released by laughter (Welsh). Endorphin is produced by the pituitary gland and the hypothalamus to cope with stress, pain, love, sexual activity, excitement and fear.
Opioids such as heroin and morphine appear to mimic naturally occurring peptides in the brain, which act as neurotransmitters with endogenous opioid activity called endorphins. Natural endorphins in the brain can kill the pain, cause joy and can cause drowsiness. For example, endorphins released by massive aerobic exercise are the cause of 'hurry' experienced by long distance runners. It is believed that morphine and heroin bind to the endorphin receptor in the brain, resulting in a decrease in the production of natural endorphin. As a result, drugs are required to replace naturally occurring endorphins and poisoning. Attempts to negate the effects of drugs, such as naprofen, naloxone, naltrexone, etc., involve the use of medicines that mimic them.
Opium is an anesthetic made from dry resins of immature capsules of Papaver Somniferum. The main constituent of opium is morphine, which has an analgesic action similar to a compound called endorphin produced in the body. Some people use it as a remedy to relieve depression and body pain. The opiate creates a sense of pleasure and excitement first. And it is part of a psychological drive that brought some kind of opium warfare and change to China. In the early 18th century, the UK and other European countries demanded more and more Chinese products, especially tea and silk. However, only the port of Guangzhou is open to foreign countries, except China, China will not receive any other payment.