The Marburg Hemorrhagic Fever Description

According to the World Health Organization (WHO), Marburg virus or Marburg haemorrhagic fever (MHF) is a very lethal virus. If epidemics occur, the mortality rate is 24 to 88%. The name of Marburg virus came from Marburg, Germany; this is the place we first discovered this year in 1967. This virus occurred in Frankfurt, Germany and Belgrade in Serbia. The main mediator of this virus is considered rousettus aegypti or fruit bat.

Marburg virus is a hemorrhagic fever virus of filamentous virus and it is also a member of Marburg virus of Marburg Marburg virus. Marburg virus (MARV) causes Marburg virus disease in human and nonhuman primates, viral hemorrhagic fevers. This virus is considered to be very dangerous. The World Health Organization (WHO) assessed it as a pathogen of risk group 4 (equivalent containment of biosafety level 4 is required). In the United States, the NIH / National Institute of Allergy and Infectious Diseases lists it as a class A priority pathogens, and the Centers for Disease Control and Prevention rank as Class A bioterrorism agents. It is also listed as an export controlled biologic by the Australian group.

MARV is one of the two Marburg viruses that cause human Marburg disease (MVD) (often referred to in the literature as Marburg haemorrhagic fever (MHF)). The other is Raven Virus (RAVV). Both viruses meet the criteria for becoming the Marburg Marburg virus species, since their genome is less than 10% away from the prototype Marburg Marburg virus or the Marburg virus mutant Mussock (MARV / Mus) at the nucleotide level. Like all mononuclear viruses, Marburg virion has a complementary 3 'and 5' end, no 5 'cap, no polyadenylation, noninfectious noninfectious, linear, unsegmented one with negative polarity Contains the present strand RNA genome. And it is not a covalent protein. The Marburg virus genome is approximately 19 kb in length and contains seven genes of 7'-UTR-NP-VP35-VP40-GP-VP30-VP24-L-5'-UTR.

Marburg's hemorrhagic fever is a rare, severe bleeding fever affecting humans and nonhuman primates. It is caused by a genetically unique zoonotic (ie animal-derived) RNA virus of the cellular virus family whose recognition results in the production of this viral family. Four Ebola viruses are the only other members of the Philovirus family. Marburg virus was first confirmed in 1967 when the bleeding fever occurred at the laboratories of Marburg and Frankfurt in Germany and the laboratory of Belgrade (now Serbia) in Yugoslavia (now Serbia). A total of 37 people are sick and they include laboratory staff, and several medical staff and their families who care for them. The first infected people were exposed to African green monkeys or their organization. In Marburg, monkeys are imported for research and production of polio vaccines.