The Importance of Ion Channels

Meshification is the absence of color on the individual's skin and eyes. This is a situation since birth. This is the importance of ion channels: Analysis of long-term QT ​​syndrome Long-term QT ​​syndrome (LQTS) is a rare congenital heart disease caused by cardiac arrest and mutation in patients affected by this syndrome. There is a high risk of sudden death in cardiac ion channels (Crotti et al., 2008). There are two special variants of long QT syndrome, one called Jervell and Lange-Nielsen syndrome (J-LN) associated with hearing loss, the other with unrelated Roman-Ward syndrome (RW) It is called.

In order to understand the importance of ion channels, it is necessary to consider that almost all cells in the body are electrically active, but unlike electronic currents that power daily life, "biological electricity" Involves the transfer of charged ions such as Na +, K + and Cl - enter and exit the cells. By these electric signals move quickly between cells and inside cells, communication between nerves, control of muscles, and how the brain works are constructed. In fact, almost all physiological processes in the body are controlled or influenced by bioelectricity. However, cell membranes are lipid bilayers that are generally impermeable to charged ions. Thus, if these ion channels are not used as a pathway for ions passing through the membrane, there is no bioelectricity

Ion channels are transmembrane proteins that help maintain the homeostasis of inorganic ions in cells by selectively introducing and transporting ions across the plasma membrane. These proteins form hydrophobic pores on the membrane to connect the extracellular matrix to the cytoplasm of the cell. These channels are not always open, but instead are controlled by external / internal chemical, electrical or mechanical factors. These external factors change the conformational shape of the channel and turn ion flow on or off. Ions rapidly flow through their open channels into their concentration gradients, causing charge differences on both sides of the membrane and generating current. The ability to control ion movement is important for many biological processes to function correctly, such as muscle contraction and nerve impulses. Especially diseases, cystic fibrosis is very deadly