The first specific genetic link to schizophrenia has been found

In a study of more than 65,000 people, we found that the risk of people suffering from schizophrenia depends to some extent on genetics.

In this study, conducted by researchers at the Broad Institute's Stanley Psychiatric Research Center, Harvard Medical School, and Boston Children's Hospital, in connection with "synaptic pruning", people with genetic motivation have schizophrenia (C4 gene) The risk is high. , Eliminating connections between neurons

These findings correspond to observations of unknown causes of schizophrenia. Synaptic pruning is particularly active when puberty, especially symptoms of schizophrenia usually occurs and neurons in schizophrenia patients show less binding than diseased uninjured neurons.

Approximately 1% of the population suffers from schizophrenia. Little is known about schizophrenia and an effective treatment is lacking compared to other serious mental illnesses such as bipolarity. In 2014, nearly 100 genomic associations with schizophrenia were found. With this new study, this number has been reduced to one. Researchers collected more than 100,000 DNA samples and narrowed down the genes associated with schizophrenia; the strongest association of C4. "Since the first explanation of schizophrenia a century ago, the underlying biology has become a black box because it is almost impossible to imitate the state of cells and animals," "Said Steven McCarroll, the main author of the study.

"The human genome provides a powerful new way of treating this disease. Understanding these genetic effects on the risk is a way to open a black box, peer into the inside and start seeing the actual biological mechanisms is."

C4 is also thought to play an important role in puberty pruning synapses and is also required for protein deposition on synapses as a process requiring pruning. It helps explain why schizophrenia patients have thinner cerebral cortex and few synapses

This research is currently paving the way for better treatment of schizophrenia. Researchers suggest that therapies that can "reduce" the level of synaptic pruning in individuals who are showing signs of early warning of schizophrenia may be useful. Eric Lander, director of the Broad Institute, says: "We are still in the early stages but have seen the ability to understand the biological mechanisms of disease in other situations.The early discovery of the biological mechanisms of cancer has led many new treatments and hundreds of other Candidate drugs have been developed Understanding schizophrenia will also accelerate progress towards this devastating disease caused by young people. "

Previous studies have discovered a genetic association between schizophrenia and personality - there are hundreds of single nucleotide polymorphisms (SNPs) associated with schizophrenia - the first time researchers share genetics The sign of the influence that we found, it helps to explain the clinical relevance between the two. To discover these findings, a group of scientists studied data from the 23 and Me Whole Genome Association study. It compares the so-called "5" personality traits - the data called neurosis, extroversion, openness to experience, familiarity and conscience - to the research results from.

Five psychoses of autism, attention deficit hyperactivity disorder, clinical depression, bipolar disorder and schizophrenia are thought to be genetically related. Using DNA from over 30,000 people diagnosed with these mental or behavioral conditions, researchers have found a specific change in the genetic code that is significantly associated with these diseases. Criminal scholar Eric Hicky said in a series of murderers and their victims: "In fact, several series murderers claim that pornography is a major factor in killing young women and children and can not be ignored There is. Steps are image poisoning, increased interest in these images, insensitivity to violence, and the resultant image.

There is no reason for schizophrenia. Because the family history of psychiatric disorders markedly increases the risk of developing this disease, research points out the possibility of genetic association. If someone has relatives of the first degree schizophrenia, such as parents and brothers, the possibility of this occurring is about 10%. Suicide is also a serious problem for isolated diseases, especially those with isolated identity disorders. Over 70% of people with isolated disabilities tried to commit suicide when they received treatment outpatient. Multiple suicide attempts are common, self-injurious behavior may be general