The Era of 'Designer Drugs': The Human Genome Project

Ali Patrinos and Francis Collins completed the human genome project within 15 years together. Ari Patrinos oversees Human Genome Research of the US Department of Energy. Francis Collins manages the National Human Genome Research Institute of the National Institutes of Health. In addition to the US Department of Energy and National Institutes of Health, several universities in the United States and other countries are participating in this project.

With the advent of the Human Genome Project and high-throughput sequencing, a stunning database filled with sequencing human genome that recognizes the genetic markers of disease was born. Furthermore, the outbreak of the "omics" era, including proteomics, allowed the identification of numerous drug targets. Combinatorial chemistry greatly facilitates improvements in the lead optimization process by allowing the chemist to expand the range of potential drug targets that it can build. This is estimated to increase the chemical search space by about two orders of magnitude.

Now 14 years since the genome project was announced, scientists say that the era of precision medical care has come. They say that the new generation of targeted drugs is increasing and use chemotherapy as the main tool of cancer treatment and protect millions of people from barbaric methods of attacking healthy cells and tumor cells maybe. These terms are often used interchangeably, but please do not confuse precision medicine with future "personalized" medicine. The latter represents a custom-designed drug specially designed for individual patients, such as Novartis's chimeric antigen receptor therapy (Car-T), which redesigns patient cells in the laboratory to attack cancer I will.