The effect of propofol lipuro with and without lidocaine on injection pain in children

OBJECTIVES: Despite the benefits of using propofol, such as providing good anesthesia and rapid recovery; the pain caused by intravenous propofol is still a problem. The aim of this study was to compare the effect of common propofol and the case of using propofol and lidocaine in combination with lidocaine for pediatric children.

Materials and Methods: This study was conducted from December 1, 2009 through May 16, 2010. Twelve children who underwent selective surgery under general anesthesia were included in four groups of prospective, randomized, double-blind trials, with 30 in each group. Conventional propofol was administered to the first group and the second group, and propofol was administered to the third group and the fourth group. In addition to propofol, lidocaine was given to the second and fourth groups. Evaluation of injection pain using Ontario Children's Hospital Pain Scale (mCHEOPS)

RESULTS: There was no difference in mean age, body weight and propofol dose between groups (P> 0.05). Comparison between groups showed no significant difference in pain scores between group 1 and group 2 (mean pain scores, 34 ± 42 and 22 ± 31 respectively P> 0.05). However, there was a significant difference between the propofol fat groups with or without lidocaine (3.20 ± 10 vs. 0.95 ± 21 points respectively; P <0.001).

Conclusion: Propofol adipose tissue has the highest pain score in the case without adding lidocaine to propofol adipose tissue, whereas the combination of propofol lipid and lidocaine shows the lowest pain score. This seems to be the best option to alleviate the pain of injection of propofol during pediatric anesthesia since the addition of lidocaine to propofol lipid minimizes the injection pain score.

The incidence of pain during propofol injection was not different from the incidence of propofol LCT pretreatment by lidocaine and the intensity of pain by propofol MCT / LCT injection significantly decreased during lidocaine pretreatment. . Therefore, the authors can conclude that injecting a new propofol MCT / LCT solution can reduce the pain caused by pretreating Propofol LCT with lidocaine. In addition, tourniquet pretreatment with lidocaine 60 seconds tourniquet can reduce the pain of propofol MCT / LCT injection prior to propofol injection.

Pain during injection of propofol: combination of propofol LCT and propofol MCT / LCT or without lidocaine pretreatment

OBJECTIVES: Despite the benefits of using propofol, such as providing good anesthesia and rapid recovery; the pain caused by intravenous propofol is still a problem. The aim of this study was to compare the effect of propofol with or without general propofol and lidocaine to painful children. Materials and Methods: This study was conducted from December 1, 2009 through May 16, 2010. Twelve children who underwent selective surgery under general anesthesia were included in four groups of prospective, randomized, double-blind trials, with 30 in each group. Conventional propofol was administered to the first group and the second group, and propofol was administered to the third group and the fourth group. In addition to propofol, lidocaine was given to the second and fourth groups. Evaluation of injection pain using Ontario Children's Hospital Pain Scale (mCHEOPS)

Conclusion: Propofol adipose tissue has the highest pain score in the case without adding lidocaine to propofol adipose tissue, whereas the combination of propofol lipid and lidocaine shows the lowest pain score. This seems to be the best option to alleviate the pain of injection of propofol during pediatric anesthesia since the addition of lidocaine to propofol lipid minimizes the injection pain score.

Background: Propofol injection pain is considered a problem during clinical anesthesia. A systematic review of the effects of lidocaine on pediatric pain relief has not been determined. The purpose of this study was to systematically evaluate the effectiveness and safety of this intervention. Method: The literature search was conducted on May 31, 2016 in the PubMed, Ovid EMBASE and Cochrane databases. Lidocaine was used in all randomized controlled trials to treat pain in children with propofol injection. The main results were the incidence of injection pain and the incidence of propofol injection pain. Combining the data, we calculated the relative ratio and its associated 95% confidence interval. Meta analysis based on Cochrane Reviewer's Handbook and PRISMA Statement

Effectiveness of lidocaine in prevention of incidence and severity of propofol related pain in children: meta-analysis of randomized controlled trials according to PRISMA criteria