Thalassemia

Thalassemia More than 2,000 Americans are possessors of genetic characteristics of thalassemia, a fatal blood disorder. It is also the most common single gene disease in the world. This disease that interferes with the formation of normal hemoglobin in the blood is incurable and until recently the victims were no longer alive in the first decade of their life. Thalassemia is a serious genetic disorder that afflicts children and adults all over the world. In order to understand thalassemia, it is necessary to understand the physiological function of blood.

Thalassemia is a genetic disorder inherited from parents. There are two main types, Alpha Thalassemia and Beta Thalassemia. The severity of alpha and beta thalassemia depends on how much of beta globin 4 genes or beta globin 2 genes are missing. Diagnosis is usually done by blood test such as whole blood count, special hemoglobin test, genetic test etc. Diagnosis can be done by prenatal prenatal examination. Treatment depends on type and severity. Treatment of patients in more severe conditions usually involves periodic blood transfusions, iron chelation and folic acid. Iron chelation can be carried out using deferoxamine or deferacylox. Occasionally bone marrow transplantation may be an option. Complications include iron overload caused by blood transfusions, causing heart and liver diseases, infections, osteoporosis. If the spleen is excessively dilated, surgical resection may be necessary.

Alfa thalassemia, moderate thalassemia, curry anemia, there are several types of thalassemia. The symptoms and symptoms you experience depend on the type and severity of your condition. Some babies show symptoms or symptoms of thalassemia at birth, and these symptoms and symptoms may develop within 2 years of birth. Some people with only one diseased hemoglobin gene have no symptoms of thalassemia at all. The type of thalassemia you suffer depends on the number of genetic mutations you inherit from your parents and on which part of the hemoglobin molecule is affected by the mutation. The more mutated genes, the more serious the thalassemia becomes. Hemoglobin molecules consist of alpha and beta parts that may be affected by mutation