Study: Mesenchymal Stem Cells (MSC)

Chapter 1 Introduction Mesenchymal stem cells (MSCs), also known as bone marrow stromal cells, are composed of a small number of pluripotent progenitor cells, and have high self-renewal ability and mesenchymal mass including bone and fat It may differentiate into an analysis organization. , Cartilage, tendon, skeletal muscle (Friedenstein et al., 1974; Pittenger et al., 1999; Reyes et al., 2001). Indeed, it has been demonstrated that MSCs can differentiate into tissues of non-intermediate mass spectrometry systems such as myocardium (Armanan et al.

Mesenchymal stem cells (MSCs) are another possible alternative to cell myoplasty. Mesenchymal stem cells can be found in various tissues such as bone marrow and adipose tissue (Pittenger, 2004). An interesting mechanism by which MSC mediates cardiac function improvement is the paracrine effect. MSCs secrete soluble cytokines and growth factors that can ultimately affect adjacent cardiomyocytes (Gharaibeh, et al., 2011). Hair JM et al. (2009) We studied the effectiveness of intravenous allogeneic mesenchymal stem cells in myocardial infarction patients. According to this study, intravenous MSC was safe and the incidence of similar adverse events was shown in both the intervention group and the control group. Injection of MSC beneficially affects patient's functional abilities, quality of life and LV remodeling (Hare, et. Al, 2012)

The use of mesenchymal stem cells (MSC) from adult stem cells is due to potential orthopedic applications in bone and muscle trauma, cartilage repair, osteoarthritis, intervertebral disc surgery, rotator cuff surgery and musculoskeletal disorders It is used in preliminary studies. Other areas of MSC's orthopedic research include tissue engineering and regenerative medicine. Stem cells can also be used to stimulate human tissue growth. In adults, damaged tissue is often replaced by scar tissue. It is characterized by disturbance of the collagen structure of the skin, loss of hair follicles, and irregular vascular structure. However, in the case of injured fetal tissue, the injured tissue is replaced by normal tissue by the activity of the stem cells.

Umbilical cord tissue can be harvested at the same time as umbilical cord blood and contains another stem cell called mesenchymal stem cell (MSC). Mesenchymal stem cells are characterized by the ability to inhibit inflammation after tissue injury, secretion of growth factors that contribute to tissue repair, and differentiation into many cell types including neuronal cells, bone cells, adipocytes, and cartilage Has its own function. Umbilical tissue derived MSCs are increasingly used in regenerative medicine for a wide range of conditions, including heart and kidney disease, ALS, MS, Alzheimer's disease, wound healing and autoimmune diseases. Many clinical trials are already in progress and the use of MSC for stem cell therapy is being investigated. MSCs from umbilical cord blood and umbilical cord tissue are safe, easy to collect, and are a readily available source of stem cells. Cryo-Cell also offers umbilical cord tissue banking services and umbilical cord blood banks.