The struggle for control in the Ohio River basin to fight for domination in the Ohio River basin ranged from the late 1740s to the 1850s. The confusion of this century is characterized by the conflict between Native American and Britain and the United States. In the struggle over land, economic and cultural advantages, it makes each side hostile. On the other hand, expansion of the Western border will provide conditions for economic development as a legitimate world power and growth for the United States.
One of the positions of Pittsburgh in American colonial history is a struggle to dominate the strategic branch of the Ohio River. French people need to establish their own ownership in the Ohio Valley to integrate themselves in New France (Canada), New Orleans and the West of the Mississippi River. Early in the eighteenth century, when British tried to establish control over the east coast, the French were busy building the outposts and fortress along the Great Lakes. In the 1840 's, France began to move south along the Allegheny River and the Ohio Valley and expanded the scope of the new French state. A trading place and settlement have been established and the requirements for the area are considered safe
According to Iroquoy 's early history theory, after joining the alliance Iroquois invaded the Ohio Valley and became a state of eastern Ohio until today' s Kentucky looked for more hunting grounds. In the exiled Ohio River Valley there are about 1,200 people who speak Suananese such as Quapaw, Ofo (Mosopelea), Tutelo, and other tribes closely related to this area. These tribes moved to the vicinity of the Mississippi River and to the foot of the east coast.
In the early 1700s, most of Wyandotte moved to the Ohio Valley and part of Indiana. Around 1745, a large party moved from near Detroit to the current Sandusky Ohio district. With the permission of Sean and Delaware, Wyandotte made a request to the north toward the north of the Ohio River. The treaty with the United States of America in 1785 established the territorial boundaries of tribes, including the majority of Ohio and Indiana. The 1795 Greenville Treaty further restricted the addition of their land to the United States.