Sickle Cell Anemia

Also at the hospital. What is the symptom? Unbearable pain, ranked ninth in the range of 1 to 10. Yes, the hospital's strongest analgesic is needed to relieve pain. Yes, this is the fourth time in a month and a half. No, the patient is not a drug addict - patient is sickle cell disease. Sickle cell disease (SCD) is a blood disease that affects red blood cells. Sickle cell anemia, one of the most common forms of SCD, has numerous pain symptoms, but there are several treatments.

In humans, sickle cell anemia is a hereditary disease in which blood cells have mutants of oxygen binding protein hemoglobin. Because sickle cell anemia is caused by a single amino acid mutation of hemoglobin, it is considered as a disease of primary structure of protein. 13). Normal blood cells are spherical, but those with this mutation make sickle shaped red blood cells. Normal blood cells are elastic and can flow freely through veins, but sickle cells are very hard and often can not move with vein branches. This occlusion causes the downstream oxygen tissue to become poor, causing many medical problems including a decrease in life expectancy. Once the body is stuck and destroyed, the body recognizes them. Healthy red blood cells usually survive between 90 and 120 days, but sickle cells have a life span of 10 to 20 days. 14)

Sickle cell anemia is a blood disorder affecting erythrocytes. Normal red blood cells are round. In people with sickle cell anemia, substances in hemoglobin - erythrocytes - become incomplete, changing the shape of erythrocytes. Defective hemoglobin called hemoglobin S (HgbS) replaces normal hemoglobin called hemoglobin A (HgbA). As time goes on, red blood cells become hard, shaped like crescent shaped satellites and sickles. In the United States, the disease is most common among African Americans (about 1 in 400 African Americans) and Caribbean Hispanics (1 in 1,000 to 1,400 Hispanics). The disease is seen all over the world in the Arab, Greek, Italian, Sardinian, Turkish, Maltese, South Asian breeds.

Sickle cell anemia This hereditary and sometimes severe condition is hereditary hemolytic anemia. It is caused by defective hemoglobin, forcing red blood cells to have an abnormal crescent shape. These irregular blood cells die prematurely and result in a chronic deficiency of red blood cells. Anemia may be a complication of malaria. If traveling to a place where malaria is prevalent, please consult your doctor about taking preventive medicine. In areas where malaria is common, prevention includes reducing exposure to mosquitoes, eg using a pesticide-treated net