Severe Combined Immunodeficiency Disorder Analysis

Severe combined immunodeficiency syndrome (SCID) is a rare disease of people with little or no immune system. This is because "some cells (T cells and B cells) associated with infection of the immune system are missing or ineffective" (Puck). Therefore, it is very sensitive to various infections such as viruses, bacteria and bacteria. "There are about 100 kinds of SCIDs (packs)." The two most common types are X-SCID and ADA SCID. X - SCID is caused by mutation of X chromosome.

Immune deficiency is one of many diseases that attacks the immune system. In these diseases, the immune system has the problem of rendering the system dysfunctional. This may be due to genetic trait or congenital disease (6). The most common immunodeficiency disease is severe combined immunodeficiency disease (SCID), also known as "form boy" disease, Di Saint George syndrome and ig A deficiency (18). Autoimmune diseases attack the immune system by considering the body that the organ is a foreign invader. When this occurs, phagocytic cells and lymphocytes activate healthy tissues and organs and destroy them. Common autoimmune diseases are lupus, scleroderma, adolescent dermatomyositis and juvenile rheumatism. The severity of AN disease can vary widely (19). Some can only cause localized swelling and inflammation by attacking joint tissues, others cause death by attacking important organs.

Severe combined immunodeficiency represents a serious defect in the development of T lymphocytes and B lymphocytes (development of leukocytes), resulting in significant sensitivity to severe complex infections. (Leukocytes are necessary for normal immunity.) The onset of infection usually occurs within 6 months of age. Severe combined immunodeficiency is considered the most serious primary immune disease. Diseases of this group are caused by the inheritance of abnormal genes from one or both parents. The most common form exists in men and is transmitted through the abnormal X chromosome provided by the mother. The second most common defect is transmission to infants. This is because parents contribute to abnormal genes that control the production of cellular enzymes (adenosine deaminase (ADA) or nucleoside phosphorylase) necessary for immunogenesis. (This kind of inheritance is called autosomal recessive inheritance.)