Severe Burns: Neutrophil and Complement Levels

The mortality rate of burned patients continues to be stable at 5 to 10%, and 75% of deaths are related to sepsis (2). To understand why, we must reveal the innate nature of these patients' innate immune system. The innate immune system is the first line of defense and pathogens from the outside world. Because of the nature of the thermal damage to the tissue, the first line of defense of the burned patient suffers a double strike. The increase in neutrophils is essentially responsive to the number of bulges activated at the tissue level (1), but the skin barrier is destroyed and inflammation begins.

C5a peptidase cleaves an effective neutrophil chemotactic factor called C5a produced by the complement system. C5a peptidase is required to minimize the influx of neutrophils in the early stages of infection when bacteria try to colonize host tissues. The C5a peptide is necessary to degrade the neutrophil chemoattractant C5a but in the early stages of infection it is not necessary for S. pyogenes to prevent the influx of neutrophils as a bacteria through the fascia. Affected tissues of patients with severe necrotizing fasciitis lack neutrophils. The serine protease SCPC released by S. pyogenes plays a role in preventing the migration of neutrophils to spread-spectrum infection. ScpC degrades the chemokine IL - 8, otherwise it will attract neutrophils to the site of infection.

Neutrophils and macrophages are phagocytes that spread throughout the body to follow invading pathogens. Neutrophils are generally found in the blood, the most abundant type of phagocytic cells, usually 50% to 60% of the whole circulating leukocytes, furthermore neutrophil killing and basketball by neutrophil subpopulation Players also occupy. . As a result of the inflammatory process, particularly the acute phase of bacterial infection, neutrophils are directed to inflammation in this process known as chemotactic site migration, but usually the first cells reach the site of infection. Macrophages are present in tissues and produce a wide range of chemicals including enzyme arrays, complement protein multifunctional cells, and cytokines. They also act as body scavengers to eliminate debilitated cells and other debris and act as antigens. Presentation of cells to activate the adaptive immune system