Scale-free Dynamics and Critical Phenomena in Cortical Activity

Rent from the world's largest e-book store and save it. Read notes on the Web, tablet and on the phone and highlight it and take notes

Presentation Date: April 18 Speaker: David Cai, New York University Topic: Large Scale Neuron Network Dynamics Model Abstract: Experiments have shown that spontaneous cortical activity regulates stimulus-inducing activity and is associated with behavior without sensory input It was shown. In the visual cortex, there is a close relationship between ongoing spontaneous activity and spontaneous firing of individual neurons. These spontaneous cortical states have dynamic switching, which can span multiple super columns and is closely related to the pattern.

In fact, the cortical-related phenomenon is caused by CSD, which is also a cause of a precursor to migraine. Cortical diffuse depression is a progressive depolarization wave that passes through the cerebral cortex at a rate of 3-5 mm / min with a temporary neuron-induced wavefront and suppression of subsequent neural activity. Because the CSD passes through the cerebral cortex, regardless of functional division and vascular area, the heredity of heredity of inheritance of the aura may be different from other or unstable seizures. Several authors speculate that CSD may also induce migraine attacks in the form of migraine without inducing a downstream nociceptive pathway.

Cortical diffuse depression (CSD) is a process in which migraine is accompanied by aura, in which the activity of the brain increases, the subsequent activity decreases, and slowly spreads along the surface of the brain. The wave of brain activity passes through the part of the brain that often deals with vision, corresponding to the typical visual aura of migraine. Studies that migraine with aura may be associated with small areas of stroke-like brain injury caused by transient oxygen level reduction (related to CSD), which prevents normal cell function and swelling of cranial nerve cells . Animal experiments have also shown that CSD stimulates the trigeminal nerve to transmit pain signals, causing inflammation of the membrane surrounding the brain. CSD inhibitors such as tonabersat are used in clinical trials to treat migraine and other neurological disorders