Rotavirus

Every year, about 1 million children die worldwide. Without attention, intruders secretly invade, and the number continues to increase over time. These children are victims of rotavirus causing severe diarrhea in children. This rotavirus dominates the human gastrointestinal tract, invades that cell, and hijacks its protein synthesis machinery. This inhibits normal protein production and is beneficial to the Virus Forces. The affected children are unlikely to recover, but now you can see the faint light of hope - the secret is the unique structure of the virus - the tunnel like the fate of the virus may be sealed I do not.

Rotavirus infection or gastroenteritis is caused by rotavirus. Among the eight viruses of this type, rotavirus A is the most common species, which causes more than 90% of human rotavirus infection. This infection is highly contagious and the virus diffuses through the fecal - oral route. Sometimes infection spreads to other people 10 days after symptoms disappear from diarrhea. More than 450,000 children under the age of 5 die every year from rotavirus infection worldwide

Before the introduction of rotavirus vaccine almost all children in the US were infected at the age of 5, but rotavirus infection had 400,000 visits, 200 thousand emergency visits, 55 000 to 70 000 hospitalization, and Brought about 20 to 60 deaths annually. Recently, rotavirus vaccination observed a very slight increase in the risk of complications. And it will lead to a better recommendation for parents with better education and children with a history of status disease. This shows that a monitoring system after vaccination is an excellent way to help scientists and physicians detect extremely rare events. !

The first rotavirus vaccine, RotaTeq, was originally made from rotavirus strains isolated from calves. Human rotavirus proteins that induce protective antibodies but cause no disease are also added. This calf rotavirus, which does not cause childhood disease, combines with human rotavirus protein to prevent disease and protect infants from disease and immunity. In 1999, another rotavirus vaccine called Rotashield® was excluded from the market. This is because it turned out to cause a rare ileus obstruction affecting about 10,000 children. The Rotashield vaccine was originally isolated from monkeys and made using rotavirus strains that are no longer used in the United States.