Rhabdomyosarcoma

Recently, we are studying genetic diseases. We have the opportunity to choose genetic diseases we want to know by writing papers on disease. The immediate theme is that all of Milford High School is near the house. With recent disappointing losses, Milford lost one of its student groups. Rhabdomyosarcoma is a soft tissue cancer that occurs in adolescent muscle cells.

Undifferentiated (undifferentiated) rhabdomyosarcoma, also known as polymorphic rhabdomyosarcoma, is the final variant of RMS that is recognized in most classification systems. Undifferentiated rhabdomyosarcoma is defined as the presence of undifferentiated cells with large leafy chromatin nuclei and multipolar mitotic maps. These tumors show high heterogeneity and poor differentiation. Undifferentiated cells may be diffuse or focal, and diffuse changes are associated with poor prognosis. It happens most frequently in adults, rarely in children, and often seen in limbs. Due to the lack of identifiable separation between cancers of this type, clinicians often classify undiagnosed sarcomas as undifferentiated RMS with little or no discernible characteristics. It is the most aggressive RMS and usually requires intensive care

Various classification systems have been proposed to guide management and treatment and the most widely used classification system is "international classification of rhabdomyosarcoma" or ICR. It was created in 1995 by IRSG as a series of four multi-institutional tests designed to study performance, histology, epidemiology and treatment of RMS (IRSG I-IV). The ICR system is based on prognostic indicators identified by IRSG I-IV. Because polymorphic rhabdomyosarcoma usually occurs in adults, not children, it is not included in this system. Curative rhabdomyosarcoma is not included in the system due to its rare performance and weak classification scheme

Rhabdomyosarcoma usually has certain chromosomal abnormalities in tumor cells, which is the cause of tumorigenesis. Children with fetal rhabdomyosarcoma usually have chromosome 11 abnormality. In alveolar rhabdomyosarcoma, there is usually a rearrangement of chromosomal material between chromosome 2 and 13. This rearrangement changes the location and function of genes and causes the fusion of genes called fusion transcripts. The patient's abnormal fusion transcript contains two genes called PAX 3 and FKHR. This important finding promotes the diagnosis of rhabdomyosarcoma