Resistance of M. Tuberculosis

Introduction Tuberculosis infects over 8 million people each year. About 2 million people die due to complications each year because they suffer from organisms that cause tuberculosis. Tuberculosis is the second most common cause of infection worldwide. The incidence of tuberculosis has gradually declined, but new barriers to effective treatment are emerging. One such challenge is the emergence of disease in the form of multidrug resistance (MDR) and extreme drug resistance (XDR).

Drug-resistant Mycobacterium tuberculosis infection is a serious threat in the United States and a more immediate threat on a global scale 4, 12 The World Health Organization reported that 170,000 people died of drug-resistant TB (TB) infection in 2012 doing. .4, 12 M Tuberculosis is the most common in airborne transmission. Infections caused by this bacterium can occur anywhere in the body, but in most cases it will occur in the lungs 5. 5. 10 828 tuberculosis cases reported in the US in 2011 are resistant to antibiotics Found. The main factors leading to drug resistance of tuberculosis are incomplete, inaccurate, or not functioning, and the lack of new medicines 5.

A major change in the severity of tuberculosis is the emergence of multidrug resistant strains. These M. tuberculosis strains are resistant to antibiotics, rifampicin and isoniazid, which were previously effective against them. Because XDR-TB is resistant to all the most effective antibiotics, it is most difficult to treat. In 2012, an estimated 35 million people are infected with HIV, more than 2 million people are newly infected each year and 1.6 million people died. Secondary tuberculosis infections account for approximately 25% of all AIDS-related deaths. The virus spreads through sexual contact, body fluids and contaminated needles