Rampant use of antibacterial nanosilver is a resistance risk

Silver nanoparticles are more commonly used in everyday products such as toothbrushes and toothpaste, baby bottles and pacifiers, bedding, clothing, household items, etc., in addition to use in medicines such as wound dressings and catheters, in addition to antibacterial effect It is becoming. Incorrect assumption that ordinary ones should be "clean" microorganisms

Dr. Cindy Gunawan, a nanobiologist and research supervisor at the Sydney Institute of Technology at Sydney Institute of Technology, has developed resistance to nanosilver, due to 'real threats', through microorganisms in the human body He said that commercialization should be used as it spreads. The alarm rang. And environment

Dr. Gwawan and Professor Liz Harry, director of the Squirrel Institute, has been working with researchers at the University of New South Wales to investigate over 140 marketed medical devices including wound dressings, trachea and catheters, and dietary supplements And cooperated with overseas researchers. It is promoted as an immunopotentiating agent and sprayed from the throat and nasal cavity

Their opinion articles by ACS Nano conclude that the use of nanosilver for these items may lead to long-term exposure to biologically active silver. This exposure creates conditions for the development of microbial resistance

The use of silver as an antimicrobial agent dates back centuries ago. For example, its ability to remove pathogens while having low toxicity to human cells has been widely used to treat burns or purify water. Recently, ultra small (less than 10,000 mm) silver nanoparticles were designed for antimicrobial purposes. Their commercial attractiveness lies in their superior effectiveness below "bulk" silver concentration.

"Nanosilver is an antimicrobial agent whose reliability proved to be compromised by the commercialization of fear of bacteria," Dr. Gwawan said.

"You need to use it wisely as you need to approach an antibiotic.Nano Silver is a useful tool, but it should be used with caution only when the benefits outweigh the risk.

"People need to understand their scope of use, but more importantly, they need to realize that the presence of nanosilver has been shown to result in antibiotic resistance."

Dr. Gunawan said that a targeted monitoring strategy is needed to monitor the occurrence of any resistance.

Professor Harry said that these findings made a tremendous contribution to coping with the global antibiotic resistance crisis.

"This research highlights our health and environmental threats due to inappropriate use of nanosilver as an antibacterial agent in general households and consumer products," she said.

More information: Cindy Gunawan et al. Universal and indiscriminate use of nanosilver: Possibility of true microbial tolerance, ACS Nano (2017). DOI: 10.1021 / acsnano.7b01166

The antimicrobial activity of ionic silver and nanosilver is related to the transmission of only silver resistant resistance mechanism, indicating that the genetic mobile element (GME) represents a possible transmission pathway of nano silver resistance. An example is an explanation of the MDR strain showing the original antibiotic and metal ion insensitivity pattern of Salmonella typhimurium: resistance to silver nitrate, mercuric chloride, ampicillin, chloramphenicol, tetracycline, streptomycin and sulfonamide (McHuhh). 1975 and so on). Recently, plasmids used to screen such large MDR phenotypes are used to screen for the antimicrobial activity of silver complexes. Wright et al. (2012) reported that GME was able to reduce the sensitivity of various silver kappa complex derivatives to susceptible strains. This suggests that related resistance genes targeting other antimicrobial agents may be beneficial for expanding SCC resistance. 1999 b)

Microsoft Word - Final_Opinion_Health's exposure to Nano silver will be released on 13th June 2014. .docx

Silver (Ag) nanomaterials (nano silver) are now widely used for their antibacterial activity. In healthcare, nanosilver has been used as an antibacterial agent like a bandage in wound dressings to protect patients suffering from severe burns from infection (Wijnhoven et al, 2009b). It is also used for catheters to prevent the formation of infectious biofilms (Rai et al., 2009, Silver 2006). As the price of medical applications for nanosilver goes down, their use is expected to increase. Nano silver is also used for consumer products such as sports woven fabrics, other fabrics, detergents and deodorants.

Microsoft Word - Final_Opinion_Health's exposure to Nano silver will be released on 13th June 2014. .docx