Polycyclic Aromatic Hydrocarbons and Association with in Uterine Exposure and Asthma

Scientists have studied the influence of polycyclic aromatic hydrocarbons on many of human health defects, one of which is asthma. Asthma is a chronic disease of the respiratory system. The respiratory system, especially the muscles of the lungs and trachea, become tight and the path of air narrows. Respiratory contractions cause many symptoms including severe breathing and chest tightness (Friis, 2012). Asthma is considered the most common long-term disease in the United States alone, especially affecting children (Al-Daghri et al.

Polycyclic aromatic hydrocarbons are toxic environmental pollutants and are involved in the pathogenesis of various diseases including cancer (1). Benzopyrene (BP) is a well-known ubiquitous carcinogen, a polycyclic aromatic hydrocarbon compound which is activated by the CYP1A cytochrome P450 (CYP 450) enzyme to form a highly mutagenic reaction electrophile, benzo Form pyridine. Diepoxide (BPDE)) (2). Phase II enzymes catalyze the detoxification of BPDE, but some reactive electrophiles covalently associate with DNA to form adducts. Unrepaired / mismatch adducts cause mutations in genes involved in proliferation, proliferation, and apoptosis, which ultimately causes diseases such as cancer. This indicates that the Phase I and Phase II enzymes play an important role in the metabolism of carcinogens and can therefore be an important target for chemoprevention.

Carcinogenicity vol. 29 no.5 pp. 1022 - 1032, 2008 doi: 10.1093 / carcin / bgn 064 Advance access issue March 4, 2008

Scientists have studied the influence of polycyclic aromatic hydrocarbons on many of human health defects, one of which is asthma. Asthma is a chronic disease of the respiratory system. The respiratory system, especially the muscles of the lungs and trachea, become tight and the path of air narrows. Respiratory contractions cause many symptoms including severe breathing and chest tightness (Friis, 2012). - Asthma is a respiratory disease characterized by dyspnea due to temporary narrowing of the bronchus branching from the trachea to the lungs. Attacks are usually caused by allergic reactions to antibiotics such as grass and tree pollen, fungal spores, fungi, animal dander, certain foods, but also caused by atmospheric chemical irritants or respiratory infections There is a possibility.