Point-of-Care Coagulation Platforms for Thrombophilia

aPTT is a routine examination for the diagnosis and monitoring of heparin therapy, mainly leading to prolongation of aPTT by inhibition of thrombin (Arbring et al., 2013). aPTT is the most suitable test for venous thromboembolism standard treatment, but it is necessary to monitor every 6 hours to control heparin with an aPTT ratio corresponding to 0.2 - 0.4 U / ml heparin level (1.5 - 2.5 times). At the end of the plasma, the aPTT test was only able to monitor UFH treatment as it was unable to cross-link thrombin for short chain LMWH (Mina et al., 2010).

Certain blood tests may indicate recently that someone had a heart attack. If you have thrombosis or a family history of less than 40 years of age and have experienced recurrent thrombosis, you will be screened for the trend of thrombosis (a disease where blood abnormally coagulates and is at increased risk of thrombosis) is needed. In general, blood diluents such as warfarin *, heparin (unfractionated heparin, or low molecular weight heparin such as enoxaparin, dalteparin or tinzaparin), fondaparinux or oral anticoagulant (eg, dabigatran, ibar) are used It is recommended. Shaban) The choice of blood diluent is highly personalized; it is based on medical history, preferences, other health problems, costs and convenience. After diagnosing a bleeding thrombus, these medications may last several months.

Coagulation is the process by which blood forms thrombi. Therefore, anticoagulation therapy using a blood diluent such as warfarin is used to treat cardiac patients or mechanical heart valve (MHV) replacement surgery to prevent thrombosis and ultimately stroke can do. Demand for anticoagulant therapy is also rising with the increase in the number of elderly people, prevalence of chronic heart disease prevalence, and the occurrence of diseases such as atrial fibrillation (AF). For these patients, it is necessary to periodically test the International Standard Ratio (INR) level to confirm the correct dosage and the effectiveness of that treatment. Incorrect doses can cause complications such as bleeding or stroke if not properly managed and controlled