Phosphorylation, oligomerization and self-assembly in water under potential prebiotic conditions

Prebiotic phosphorylation of (pre) bio-substrates under aqueous conditions is an important step in the origin of life. Previous studies are limited in their success and / or require unique environments that are incompatible with subsequent generations of corresponding oligomers or higher structures. Here we demonstrate a variety of (pre) phosphoric acid phosphate (DAP), a rational probiotic agent made from trimetaphosphate effective (amide) by aqueous phosphoric acid solution (solution / paste) I will. Biological structural units (nucleoside / tide, amino acid and lipid precursor) conditions do not require a condensing agent. It is noteworthy that higher structures (oligonucleotides, peptides and liposomes) are formed under the same phosphorylation reaction conditions. Under similar reaction conditions, this reasonable prebiotic phosphorylation process can achieve systemic chemistry of three (pre) bio-related molecules and their oligomers in a single-pot aqueous environment.

According to the TSRI team, diamine phosphate may have existed in the earth's water billions of years ago, and these conditions do not prevent it from acting as a phosphorylating agent. Experiments have shown that DAP can phosphorylate nucleosides that are part of RNA and DNA. With the addition of simple (and abundant) organic catalyst imidazole, these nitrogen base chains combine with each other and appear to be very short RNA strands. Imidazole also catalyzes the phosphorylation of glycerol and fatty acids with DAP and combines them to form self-assembled capsules called vesicles (see above). This is the original version of the phospholipid membrane we see today in the cell. Phosphorylation by amino acids DAP also binds them to short peptide chains - protein building blocks

Prebiotic phosphorylation of (pre) bio-substrates under aqueous conditions is an important step in the origin of life. Previous studies are limited in their success and / or require unique environments that are incompatible with subsequent generations of corresponding oligomers or higher structures. Here we demonstrate a variety of (pre) phosphoric acid phosphate (DAP), a rational probiotic agent made from trimetaphosphate effective (amide) by aqueous phosphoric acid solution (solution / paste) I will. Biological structural units (nucleoside / tide, amino acid and lipid precursor) conditions do not require a condensing agent. It is noteworthy that higher structures (oligonucleotides, peptides and liposomes) are formed under the same phosphorylation conditions.

Interaction with catalytic RNA enhances the range and efficiency of catalytic RNA molecules as amino acids gradually emerge in the world of RNA under prebiotic conditions. Thus, the driving force for the evolution of ribosomes from ancient self-replicating machines to their current form of translational machinery is the selective pressure to bind the protein to the ribosomal self-renewal mechanism, thereby increasing its capacity obtain. Self replication

Phosphorylation of the activated S cyclin-CDK complex constitutes the protein of the pre-replication complex assembled during the G 1 phase of the DNA replication origin. Phosphorylation serves two purposes: to activate each assembled pre-replication complex and to prevent the formation of new complexes. This ensures that each part of the cell's genome is replicated only once. Because daughter cells lacking all or part of an important gene die, the reasons for preventing replication gap are very clear. However, owning further copies of specific genes due to the gene copy number effect is also detrimental to daughter cells.