Penicillin Resistance

What is happening here Many factors are involved in the treatment of diseases caused by drugs. The ability of a drug to reach the infected area depends on absorption, distribution, metabolism, and excretion. This ability can be achieved only by a transport mechanism in barrier epithelial cells. Most drugs have positive or negative charge in the body, so they are polar and hydrophilic. This is important as it prevents drugs from penetrating the various membranes in the body. Because of these characteristics, our bodies require special transport elements to ensure that the medicines function.

Methicillin-resistant Staphylococcus aureus (MSSA): Penicillin-resistant penicillin is the best drug for all S. aureus infections caused by penicillin-resistant MSSA strains. These medicines have a bactericidal effect and are widely accepted as other penicillins as well as low incidence of adverse reactions. Various penicillinases penicillin are available including isoxazolyl penicillin cloxacillin, diclocillin, flucloxacillin and oxacillin for oral and parenteral use, and methicillin and nafcillin for parenteral use. There is no significant difference in efficacy between these drugs and they have similar pharmacokinetic characteristics. Continuous infusion of these drugs has been used to increase severe staphylococcal infection with satisfactory results, especially as outpatient treatment (223).

S. pneumoniae develops resistance to many drugs, which is a particular problem. In the 1960's, scientists discovered penicillin-resistant pneumococcal strains spreading all over the world. In most cases, penicillin-resistant bacterial strains are also resistant to other drugs such as erythromycin, chloramphenicol, trimethoprim-sulfamethoxazole and tetracycline. These strains are called "multidrug resistance".