Patient With Alzheimer’s Disease (AD)

Introduction: Alzheimer's disease (AD) is a fatal neurodegenerative disorder that is becoming more common due to the increase in the elderly population over the age of 65. [1] If an effective treatment strategy can not be achieved, it is estimated that AD affects 66 million people by 2030 and affects 115 million people by 2050. [2] Clinically, AD is characterized by cognitive impairment, progressive interference in the activities of daily living, and worsening of numerous neuropsychiatric symptoms and behavior. [3-8] AD not only caused catastrophic pain to the patient, but also caused devastating pain to caregivers.

Patients with Alzheimer's disease (AD) experience a gradual and progressive decline in memory and cognitive abilities, as well as other symptoms, due to the spread of damage in the brain. Typically, the disease is divided into three phases, which serve as guidelines for them and record disease progression based on their symptoms. They are mild (early), moderate (moderate) and severe (late) AD. People suffering from early Alzheimer's disease are almost self-sustaining and usually can take the same activities, such as driving, working, participating in social activities, before the onset of the disease. However, they may need to help with more complicated tasks. The most common function of mild AD is memory and caution error, making it more difficult to learn new things remembering recent events.

Patients with Alzheimer's disease (AD) and Parkinson's disease can be distinguished based on specific cognitive and behavioral characteristics. The execution of different tests resulted in similarities and differences between the two sets of cognitive profiles. There are similarities between groups in terms of visual movement speed and attention, but there are differences in execution function, memory, sequence function, setting transition, and fluency. Therefore, the cortical patient (AD) had significantly less memory ability than the subcortical group (Parkinson's disease), while the latter group showed greater defects in the function of execution. In this study, patients with high cognitive function (ie, higher education, occupation, etc.) achieved higher neuropsychological outcomes than those with lower cognitive function, an important role in cognitive decline and incidence of dementia It fulfilled. protection

Orlazarov et al. In their thesis (2005), "Brain deposition of beta-amyloid (Aβ) peptide is the brains of Alzheimer's disease (AD) patients and transgenic mice co-expressing familial AD-related APP and PS1 mutants. Invariant Pathologic Markers We found that exposure of transgenic mice to "enriched environment" resulted in increased brain Aβ levels and amyloid deposits compared to animals raised under "standard house" conditions Significantly decreased. The story that humans use is "rich environment" - a close combination of heroic events and actions - the possibilities are varied to completely unexpected uncertainty in a completely chaotic way. Unlike other stories, reliability is fluctuating in magical fairy tales.