Paracetamol: Uses and Risks

1-acetaminophen (PCT), acetaminophen or N-acetyl-p-aminophenol (APAP) is an acylated aromatic amide derived from aniline [1] [s 073] [so 96089]. It has antipyretic and analgesic effects, it is a nonsynthetic opioid. [3] In 1893, acetaminophen was first described as an analgesic and an antiepileptic drug. [s 17] In 1866, another acetanilide derived from aniline was found to have an antipyretic effect and began to be used to treat fever. However, it has been proven to be toxic. Therefore, other derivatives derived from aniline such as acetaminophen and phenacetin are also considered to be toxic.

The analgesic and antipyretic actions of acetaminophen were first discovered at the end of the 19th century. Both drugs have been used to treat mild to moderate pain, acetanilide and phenacetin. In 1889 it was confirmed that acetaminophen was excreted in the urine of patients taking these drugs. In 1948, Brodie and Axelrod determined that acetaminophen is the major metabolite of phenacetin and acetanilide. This led to the belief that the clinical effect of these two drugs is entirely due to the rapid conversion of acetaminophen. Thereafter, it was demonstrated that phenacetin itself has some activity, but since it is mostly converted to acetaminophen, it is only at very high doses. However, so far, due to some indirect evidence of its role in causing analgesic nephropathy, non - berberine is considered to be more toxic than acetaminophen. With the popularity of paracetamol, phenacetin disappeared from the market. ,

Various methods have been used to analyze acetaminophen. Since paracetamol is usually an integral part of complex analgesics tablets, most of current research aims to find a way to analyze drug combinations. Liquid chromatography is widely accepted for the detection of acetaminophen. According to Shah et al., Reversed phase high performance liquid chromatography (RP-HPLC) is most suitable for simultaneous analysis of acetaminophen and lornoxicam in tablet formulations. In this work we used a Brownleigh C - 18, 5 μm column with an internal diameter of 250-4 mm in isocratic mode and a mobile phase containing 0.05 M potassium dihydrogen phosphate: methanol (40: 60, v / v) did. The flow rate was 0 ml.min -1 and the effluent was monitored at 266 nm. The retention time of acetaminophen was 7 minutes. The linear range of acetaminophen is 5 to 200 μg · ml -1. Shah's method will be reproduced in this study