In the 14th century, more than one-third of the world's population was killed by black plague. Two hundred years later, influenza has given out an additional 15 million people. After that, in the early 20th century, Spain influenza infected 500 million people in just two years. Since the Bible era, epidemic diseases have influenced the world. These embarrassed viruses once converted the thriving town into a lonely ghost town. Civilization was reformed, culture and politics changed, and national hope was broken. When will the next major outbreak occur?
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The first school in Puerto Rico and the first US school after Puerto Rico became the territory of the United States was Escuela de Gramatica (Grammar School). The school was founded in 1513 by Bishop Alonso Manso and is in the construction area of San Juan Cathedral. School is free, the courses taught are Latin, literature, history, science, art, philosophy, and theology. Due to the possibility of huge wealth, many European powers tried to deprive Spain from the American continent in the 16th, 17th and 18th centuries. The success of the invasion was varied and eventually all the Spanish opponents failed to permanently dominate the island. In 1528, the French recognized the strategic value of Puerto Rico, dismissed and burned the town of Saint Germain in the Southwest. Before the local militia retreated them, they destroyed many of the island 's first settlements, including Guanica, Sotomayor, Daguao, Rosa etc.