Olanzapine: Are the Side Effects Worth the Risk?

As can be seen from the figure below, the prefrontal cortex is intertwined with the action of the whole brain, so it is intertwined with the whole body. The red / pink line shows the interaction between the dopamine neurotransmitter and the receptor, but dopamine does not show direct attachment to the prefrontal cortex, and the anterior cingulate cortex and the hippocampus are directly connected. Reducing dopamine may result in several distinct questions.

Most people taking antipsychotics have side effects. People taking general antipsychotics tend to have higher side effects of extrapyramidal system, but some of the atypical populations are associated with considerable weight gain, risk of diabetes and metabolic syndrome . And quetiapine is also associated with weight gain. Risperidone resembles the extrapyramidal symptoms of haloperidol. Early intervention in mental illness is based on the observation that identifying and treating someone early in mental illness improves their long-term outcome. This approach advocates the use of an enhanced multidisciplinary approach in the so-called critical period that interventions are most effective and prevent long-term morbidity associated with chronic psychosis.

a) Side effects In a short-term, placebo-controlled clinical trial, lethargy is the most common side effect associated with olanzapine. Other common side effects include constipation, dry mouth, increased appetite, weight gain (291). During initial dose titration, olanzapine may cause vertigo, tachycardia, and orthostatic hypotension with fainting in some patients. In Phase II and Phase III studies, 0.6% of patients treated with olanzapine reported fainting. In clinical trials, 0.9% of patients treated with olanzapine developed seizures. In many cases, relevant factors may cause seizures, but olanzapine should be used with caution in patients with clinical conditions related to a history of epilepsy or a reduction in the seizure threshold. A temporary rise in plasma prolactin concentration was also observed in the short term study (293)