Nurture has greater effect than nature, says study

It is well known that many features such as weight and growth are the result of the genetic makeup of organisms and the influence of environmental factors. Mutations between individuals in these traits are also affected by so-called epigenetic effects such as genomic imprinting without genetic variation. However, it remains unexplored whether epigenetic effects can interact with the environment in the same way as genotypes.

In a new study, Reinmar Hager and Jason Wolf of St. Louis's Department of Life Sciences, and their colleagues James Cheverud, even with their mothers, how their mother's environment influences gene expression, young rat weight And it showed how it affects growth. Irrelevant

Therefore, they reveal different ways in which the environment may influence gene expression methods. Researchers focus on imprinting the genome, which indicates that the environment has a major impact on how blotting affects mouse weight and growth.

The findings of Dr. Hager published in the latest Royal Society Journal B (May 27, 2009) stated as follows. "The plasticity of genomic imprints is greater than previously envisaged, for example, mothers should convey information about the environment they will grow (eg availability of resources) As young people know what will happen, they may better adapt to the environment as they can.

The team used a cross cultivation design where a mouse puppy is taken care of by herself or an unrelated mother. Then they scanned the whole genome of the offspring, found the genes affected by the mating, and found ten such loci. Among the 10 identified sites, 4 showed evidence of cross-cultural interactions occurring in pups epigenetic effects of intergenomic imprints were given primarily by their foster parents. This suggests that the mother's environment affects whether traces of the genome will occur in young people and therefore affects the weight of the mouse.

Dr. Hager said: "This research is important as it shows that genes not only interact with the environment but also show epigenetic effects, this interaction is important because the fundamental causes of weight and change are important Growth, reaction to stress, or resistance to disease.

However, the mechanism behind the interaction requires further research. "We do not know how changes in the environment will respond to changes in the epigenetic effects of future generations but we believe this will be done by changing maternal behavior and will be verified in the next study There is "

For details, refer to the following. "Maternal environmental changes caused by cross foster change the genetic and epigenetic effects of complex traits of mice." See Royal Society Journal B

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