Nerve Regeneration

Peripheral neuropathy is the damage of the peripheral nervous system (PNS). PNS helps communicate sensory information to the brain and spinal cord. Next, the brain sends back the communication to the PNS to perform certain motor functions. Damage to any part of the PNS causes various symptoms such as stinging, stinging, numbness, muscle atrophy, and even paralysis. Peripheral neuropathy is known to have about 100 types, and they are classified by the affecting nerves: sensation, exercise, autonomic nerves.

Nerve growth factor (neurotrophic factor) is a molecule that is naturally released during nerve regeneration. They are released from nerve endings, in particular after affecting nerve injury, nerve growth, differentiation and monitoring. Many of these neurotrophic factors have been isolated and have been applied to proximal nerve stumps after injury to enhance axonal regeneration. Nerve growth factor (NGF) exists in low concentrations in healthy nerves. After nerve injury, NGF is up-regulated at the distal nerve stump and plays an important role in the survival of sensory neurons and neurite outgrowth. Many other growth factors have been identified during nerve regeneration, including glial growth factor (GGF), fibroblast growth factor (FGF), glial cell derived neurotrophic factor (GDNF), neurotrophic factor 3 (NT) . -3), ciliary neurotrophic factor and leupeptin

In the last century, research of several species showed that nerve is essential for regeneration of many organs. Classical experiments of limbs indicate that denervated limbs can not be regenerated (Todd, 1823). Several neurodegenerative factors have been shown to play a role in regeneration, including the growth of fibroblasts in vertebrate limb regeneration. (FGF) Gospodarowicz and Mescher, 1980), regeneration of glial growth factor (GGF) in the zebrafish tail and regeneration of vertebrate limbs (Rojas-Muñoz et al., 2009; Wang et al., 2000) The role of nAG (Kumar et al., 2000 2007) and the role of glial derived neurotrophic factor (GDNF) in mammalian hematopoietic regeneration (Lucas et al., 2013)