Medical Definition of Benign prostatic hyperplasia

Benign prostatic hypertrophy: general noncancerous hyperplasia of the prostate. The enlarged prostate squeezes the urinary tract (urethra) passing through the center of the prostate gland and prevents urine from flowing outward from the bladder through the urethra. Abbreviation BPH. If BPH is sufficiently serious, complete blockage may occur. BPH usually develops after 30 years of age, progresses slowly and causes symptoms only after 50 years of age. Half of men over the age of 50 develop BPH symptoms, but only a few people need medical or surgical procedures. Medicines include drugs such as finasteride and terazosin. Traditionally, prostate surgery is thought to bring the greatest benefit and maximum risk to BPH. BPH is not a sign of prostate cancer. Benign prostatic hypertrophy and prostatic nodular hyperplasia

Benign prostatic hypertrophy is the most common prostate problem in males over 50 years old. In 2010, 14 million men in the United States suffer from lower urinary tract symptoms and suggest benign prostatic hyperplasia 1. Benign prostatic hypertrophy rarely develops before onset 40. Benign prostatic hypertrophy develops in about 50% of men aged 51 to 60 years and up to 90% of men over age 80. Depending on the size of the prostate gland, the severity of obstruction and symptoms is not always determined. Although few people have prostatic hypertrophy, there are few symptoms, but those with the smallest prostatic hyperplasia are obstructive and symptomatic. Less than half of all patients with benign prostatic hypertrophy have mild urinary tract symptoms

The cause of benign prostatic hyperplasia is unknown, but it mainly occurs in elderly men. A man who resected the testicle before puberty does not develop benign prostatic hyperplasia. Therefore, some researchers think that factors related to aging and testis may lead to benign prostatic hyperplasia. During the lifetime, men produce testosterone, androgens and a small amount of estrogen, estrogen. As men get older, the amount of active testosterone in the blood decreases and the proportion of estrogen increases. Scientific studies have shown that benign prostatic hyperplasia can occur because a higher proportion of estrogen in the prostate increases the activity of substances that promote prostate cell proliferation.

Benign prostatic hypertrophy is an age-related disease. The erroneous accumulation of aging theory suggests that the development of benign prostatic hyperplasia is a consequence of fibrosis and prostatic muscle tissue weakness. Muscle tissue is important in the function of the prostate and provides the power to excrete body fluids produced by the prostate. However, repeated contraction and expansion of muscle fibers inevitably results in injury and damage to muscle fibers. Muscle fibers have lower regenerability; therefore, collagen fibers are needed to replace broken muscle fibers. This errant repair may weaken the function of muscle tissue and body fluids secreted from the glands are not completely excreted. Subsequently, fluid accumulation in the glands increases the resistance of muscle tissue during contraction and expansion, and more and more muscle fibers are destroyed and replaced by collagen fibers.