MDRD for Adults (SI Units)

In adults, the most widely used formula to estimate creatinine glomerular filtration rate (GFR) is chronic kidney disease epidemiological cooperative study (CKD-EPI) equation 1 and isotope dilution mass spectrometry (IDMS) traceable kidney It is disease. Meal improvement (MDRD) studies Equation 2. The NKDEP calculator relies on a creatinine assay that is traceable by isotope dilution mass spectrometry (IDMS). All laboratories should use the creatinine method tailored to IDMS. Read more about standardization of creatinine

When reporting Scr at μmr / L, you need to use this IDMS traceable MDRD research equation equation calculator. Do not use this formula when eGFR value exceeding 60 mL / min / 1.73 m 2 is required.

GFR (mL / min / 1.73 m 2) = 175 × (Scr / 88.4) - 1.154 × (age) - 0.203 × (women 0.742) × (African African 1.212) (SI unit)

Since the reported results are normalized to an acceptable average adult surface area of ​​73 m 2 body surface area, this formula does not require body weight.

1. Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF, 3 rd, Feldman HI et al. New equation for estimating glomerular filtration rate An intern medicine 2009; 150 (9): 604-12

2. Levey AS, Coresh J, Green T, Stevens LA, Zhang YL, Hendriksen S, Kusek JW, Van Lente F; chronic kidney disease epidemiology. Glomerular filtration rates were estimated using serum creatinine values ​​normalized to alter the study equation in the kidney disease diet. Ann Intern Medicine August 15, 2006; 145 (4): 247-54

The recently proposed formula for calculating GFR is an expression developed by the kidney research group for dietary improvement. Most laboratories in Australia and the UK currently calculate MDRD estimates of GFR and creatinine measurements that form the basis of chronic kidney disease and report it. Automatic reporting by MDRD-eGFR has been widely criticized. The most commonly used formula is "4 variable MDRD". It uses four variables to estimate GFR: serum creatinine, age, race, sex. The first MDRD uses six variables, the other variables are blood urea nitrogen and albumin levels. This formula has been validated in patients with chronic kidney disease, but these two versions underestimate the GFR of healthy patients with GFR greater than 60 mL / min. This formula has not been validated in acute renal failure

In this survey we confirmed that the MCQ equation gives the highest GFR average, followed by CKD EPI and MDRD equations. However, this difference is not statistically significant. The MDRD GFR value shows a significant negative correlation with age. Regarding the calculated GFR value, there is an important correlation between the various expressions. However, there are some differences in the values ​​given by the expressions, so using one of these expressions may misclassify people as CKD. There are many differences when expressing fluctuations in various diseased populations and parameters such as age and nationality 2, 11, 12, 13. MDRD and Isotope Dilution Mass Spectrometry (IDMS) Improvements in the traceable MDRD measurement formula are speculated to be able to more generally demonstrate GFR evaluations 12 and 14.