Marburg Virus: The First Documented Outbreak of Fever

The first recorded hemorrhagic fever virus outbreak by the Marburg virus is related to wild captured African green monkeys (Chlorocebus aethiops, formerly Cercopithecus aethiops) imported from Uganda to Marburg and Frankfurt, Germany. Imported from Belgrade of Yugoslavia. Thirty-one animal workers and laboratory workers who were in direct contact with blood or tissues of recently imported monkeys during infection of Zoonotic Infection were infected with the newly discovered MBGV and 7 died.

Marburg virus was first confirmed in 1967 when the bleeding fever occurred at the laboratories of Marburg and Frankfurt in Germany and the laboratory of Belgrade (now Serbia) in Yugoslavia (now Serbia). A total of 37 people are sick and they include laboratory staff, and several medical staff and their families who care for them. The first infected people were exposed to African green monkeys or their organization. In Marburg, monkeys are imported for research and production of polio vaccines.

Marburg virus is a hemorrhagic fever virus of filamentous virus and it is also a member of Marburg virus of Marburg Marburg virus. Marburg virus (MARV) causes Marburg virus disease in human and nonhuman primates, viral hemorrhagic fevers. This virus is considered to be very dangerous. The World Health Organization (WHO) assessed it as a pathogen of risk group 4 (equivalent containment of biosafety level 4 is required). In the United States, the NIH / National Institute of Allergy and Infectious Diseases lists it as a class A priority pathogens, and the Centers for Disease Control and Prevention rank as Class A bioterrorism agents. It is also listed as an export controlled biologic by the Australian group.

MARV is one of the two Marburg viruses that cause human Marburg disease (MVD) (often referred to in the literature as Marburg haemorrhagic fever (MHF)). The other is Raven Virus (RAVV). Both viruses meet the criteria for becoming the Marburg Marburg virus species, since their genome is less than 10% away from the prototype Marburg Marburg virus or the Marburg virus mutant Mussock (MARV / Mus) at the nucleotide level. Like all mononuclear viruses, Marburg virion has a complementary 3 'and 5' end, no 5 'cap, no polyadenylation, noninfectious noninfectious, linear, unsegmented one with negative polarity Contains the present strand RNA genome. And it is not a covalent protein. The Marburg virus genome is approximately 19 kb in length and contains seven genes of 7'-UTR-NP-VP35-VP40-GP-VP30-VP24-L-5'-UTR.