Long-term Radiation-Related Health Effects in a Unique Human Population: Lessons Learned from the Atomic Bomb Survivors of Hiroshima and Nagasaki

Approximately 40% of atomic bomb survivors are still living today, about 80% of those bombed before the age of 20. The latter has just entered the cancer predisposition and the "aging disease" year. It is estimated that many of the cancers in the LSS and AHS cohort have not occurred as previously generated and recorded. This is a major uncertainty in estimating the lifetime risk of a disease that requires cancer or other measures. Therefore, continuing follow-up of the LSS cohort over the next 20 years will be an important opportunity to improve risk assessment as a child's exposure compared with adult exposure. In addition, one or both children of type A bomb survivor (F1 generation) are younger than members of the LSS cohort and have just begun to get sick. Extensive data on radiation dose, disease experience and associated disease risk factors accumulated over 60 years will provide rich information that can be mined in the coming years to address a wide range of issues related to the health effects of ionizing radiation Offers.

Regarding radiation induced mutation and the risk of offspring, the aim is that future RERF research using powerful new technologies for DNA analysis can detect increased mutation rates, or mutations It is possible to confirm that the upper limit of low rate mutation is rather narrow. In addition, the valuable and extensive biological sample resources provided by atomic-bomb survivors provide hope to investigate radiation-induced health effects mechanisms that benefit survivors and humans.

Delays in the effects on the human body due to radiation exposure to ionizing radiation have been determined by long-term epidemiological studies. A cohort study (lifespan survey) of atomic bomb survivors in Hiroshima and Nagasaki is considered the most reliable source of information for cohort size, exposure to men and women of the general population and all ages. And various doses individually evaluated. Therefore, the life survey is the basis for the risk assessment of the radiation protection system by the International Radiation Protection Committee and other authorities. Radiation exposure increases the risk of cancer throughout life and is essential for continued follow-up of survivors. Overall, survivors have a serious risk of radiation-related cancer, and those exposed to cancer are more at risk of developing older people than the elderly.

One of the most pressing problems after the future attacks on Hiroshima and Nagasaki was the effect of radiation on the health of children exposed to atomic bomb survivors. So far there have been no excessive radiation related diseases among survivors' children, but more time is needed to make a decision. But in general, the health of the new generation of the people of Hiroshima and Nagasaki makes people believe that the city will continue to rise from the destruction of the past like the flowers of the Orenda.