Linking Down’s Syndrome and Leukemia

Many times, there are links between the two diseases. Examples of associations are Down's syndrome and acute myelogenous leukemia. Down syndrome is a chromosomal abnormality, acute myelogenous leukemia is the most common acute leukemia. Patients with both diseases must be treated differently and differently than patients with only one disease. The survival rate is very high in patients with DS-AML, especially in younger patients. Their survival rate decreases as the age of the patients increases, but their survival rate is optimistic even at older age compared to the survival rate of other cancers.

Children with Down's syndrome suffer from more than 10 to 15 times more blood cancers. In particular, acute lymphoblastic leukemia is 20 times more common, acute myeloid leukemia of megakaryocytic type (acute megakaryoblastic leukemia) is seen 500 times more. Acute megakaryoblastic leukemia (AMKL) is a precursor of megakaryocytic leukemia, a megakaryocyte that forms platelets. Down syndrome acute lymphoblastic leukemia accounts for 1 to 3% of all pediatric ALL cases. The most frequent occurrence is when you are over 9 years old or when the white blood cell count exceeds 50,000 microliters. It is rare for people under 1 year old. In people without DS, DS ALL brings worse results than other ALL cases

People with Down's syndrome are at increased risk of certain diseases such as congenital heart disease, respiratory deafness, Alzheimer's disease, childhood leukemia, thyroid disease. Most of these symptoms are currently treatable, so most people with Down's syndrome are living healthy lives. And there are deep wrinkles throughout the body. Anyone with juvenous down syndrome is a unique person who may have different degrees of these features or not at all.

Children with Down's syndrome are at increased risk of thyroid disease and leukemia. They also have many colds, as well as bronchitis and pneumonia. Children with Down's syndrome should receive regular medical treatment, including vaccination for children. The National Down Syndrome Conference announced the "Preventive Medical Checklist" showing the outline of recommended examination and health examination at different age. The degree of intellectual disability of Down Syndrome differs greatly. It ranges from mild to moderate to severe. However, most intellectual disabilities are mild to moderate range. According to their physical characteristics, it is impossible to predict the intellectual development of children with Down's syndrome

Transient myeloproliferative disease, also known as transient leukemia, is associated with abnormal growth of noncancerous megakaryocytic clones. The disease is confined to individuals with genetic changes similar to Down's syndrome or Down's syndrome and develops in the infant during or immediately after birth and may occur within 3 months or in about 10% , It progresses to acute megakaryoblastic leukemia. Transient myelogenous leukemia is a symptom of preleukemia. Platelet deficiency is caused by damage to the bone marrow by replacing normal bone marrow cells with more immature leukocytes. And it is important in blood coagulation. This means that leukemia people are easily injured, excessive bleeding or acupuncture bleeding (defect)