lignocaine and propofol injection pain

Background and purpose: Propofol injection pain is an outstanding problem for children. Medium long chain triglyceride (MCT-LCT) Propofol shows promising results in adults, but effects on children have not been confirmed. In prospective observational studies, we compared the incidence and severity of pain in children with MCT-LCT and LCT propofol. Method After obtaining approval from the Institutional Ethics Committee, the study included 170 children (age range 6 months to 8 years) scheduled for various surgeries.

Background and purpose: Propofol (2,6-diisopropylphenol) for induction of anesthesia often causes mild to severe pain or discomfort of injection. A double-blind study was designed to compare the effectiveness of methylprednisolone and lidocaine in the reduction of propofol injection pain for cardiac surgery patients. METHODS: A total of 165 adult patients scheduled for selective cardiac surgery were divided into three groups: saline (S group, n = 55), lidocaine 20 mg (L group, n = 55), and methylprednisolone 125 mg. It was diluted in 2 ml of distilled water (MP group, n = 55).

INTRODUCTION: Propofol has many features of an ideal intravenous anesthetic to provide a smooth introduction and quick recovery. However, it has been reported that 10-100% of patients cause considerable pain during injection. The cause of pain after intravenous administration of propofol remains a mystery. Objective: To study and compare the efficacy of lidocaine, tramadol and ketorolac in relieving propofol injection pain. Materials and Methods: Consider the study of hundreds of adult patients (ASA grade I and II) undergoing selective surgery using propofol as an inducer under general anesthesia.

Background and purpose: Propofol is widely used for the introduction of anesthesia, but pain during injection is still a concern for all anesthesiologists. Many techniques are adopted to minimize the pain caused by propofol. A variety of serotonin-3 antagonists have been shown to alleviate the pain caused by propofol. Therefore, this placebo-controlled study was designed to compare the effectiveness of ondansetron, ramosetron, and lidocaine in the relief of pain caused by propofol during anesthesia induction.

A common disadvantage of propofol is pain during injection and lidocaine is often mixed with propofol to reduce its incidence and severity. In this study, we tried to compare propofol medium long chain triglyceride (MGT / LCT) with propofol medium long chain triglyceride (MCT / LCT) premix lidocaine prevention. Effect of propofol pain injection 200 patients were randomly divided into two groups. Propofol-MCT / LCT and physiological saline mixed beforehand were administered to group A, and group B received 20 mg of lidocaine and propofol-MCT / LCT mixed in advance before administration. The incidence of pain was 63% in group A and 15% in group B (χ 2 = 48.242, p <0.001). Conclusion Propofol MCT / LCT alone has the advantage of reducing injection pain compared to propofol MCT / LCT premix lidocaine.

Prospective randomized, double-blinded trial comparing propofol / long chain triglycerides and propofol medium / long chain triglycerides compared to lidocaine injection pain

Injection pain is due to the amount of free propofol in the aqueous phase of the emulsion. In 1997, Doenicke et al. (6) proposed the use of propofol reconstituted lipid emulsion to relieve injection pain. Propofol reconstitution contains equal proportions of medium chain triglycerides (MCT) and long chain triglycerides (LCT), compared to conventional LCT formulations. The amount of free propofol in the MCT / LCT emulsion is less than the amount of propofol LCT and is therefore considered to cause painless injections. However, recent studies have shown that propofol MCT / LCT emulsion alone causes injection pain than propofol LCT compared to lidocaine. (7, 8, 9)

Prospective randomized, double-blinded trial comparing propofol / long chain triglycerides and propofol medium / long chain triglycerides compared to lidocaine injection pain

Schaub et al. (7) The pain incidence of propofol MCT / LCT was reported to be 47% compared to 24% of patients who used propofol LCT and lidocaine. Nyman et al. (8) reported that in their pediatric patient study, 33.3% of patients received painless propofol injections in propofol MCT / LCT group but propofol was injected with propofol LCT and lidocaine. 61% of the patients receiving painless propofol were injected. Adam et al. (9) Patients receiving propofol MCT / LCT are reported to have a higher language analogue scale (VAS) than patients receiving propofol LCT and lidocaine.

Prospective randomized, double-blinded trial comparing propofol / long chain triglycerides and propofol medium / long chain triglycerides compared to lidocaine injection pain