Lassa Fever: An Old World Arenavirus

Lassa fever: Old world Arena virus abstract Lassa fever, its history, pathology, outline of influence on indigenous people. In addition, Lhasa fever is in the background of emerging diseases. Lassa Fever On January 12, 1969, a missionary nun who worked in a small town in Lhasa in Nigeria began complaining about his back pain. I think that she just pulled the muscles, she neglected the pain and kept talking about her business. However, one week later, the nurse's throat hurt so badly that it was full of ulcers and she could not swallow.

Lassa fever or Lassa hemorrhagic fever (LHF) is the acute viral hemorrhagic fever caused by Lassa virus first reported in Lhasa, Borno, Nigeria in 1969. Lassa fever is a member of the Arenavirus family. Like Ebola virus, the clinical case of this disease is more than 10 years old, but it is irrelevant to viral pathogens.

Lassa fever is a virus belonging to the Arenavirus family. Although the genus Arenavirus has been in the form of lymphocytic choriomeningitis for about 60 years, it has recently received attention for many species known as "emerging viruses" in this genus. This genus consists mainly of New World viruses including Junin, Machupo and Guanarito viruses that cause hemorrhagic fever in Argentina, Bolivia and Venezuela, and several other nonpathogenic viruses. These viruses, which have been hidden in the deepest part of the tropical rainforest for a long time, make their presence more and more familiar to tropical rain forests and other isolated areas. The main carrier, rodent Mastomys natalensis, is increasing mainly due to (indirectly) increasing numbers due to poverty and food shortages. (South, 1996)

Lassa virus is a member of the Old World Complex and belongs to the parvovirus family. Genus is a sand virus, its species is its name, Lhasa virus. It belongs to the fifth group (V) of Baltimore virus classification including Ebola, measles, rabies and influenza. This type of virus is a negative sense single-stranded RNA genome, and it has a sandy appearance due to the presence of ribosome. The virus particles are spherical and consist of an envelope and two nucleocapsids, the filaments forming a circle. The shell is wrapped. The envelope contains a glycoprotein which is post-translationally cleaved into glycoproteins 1 and 2 (GP 2). GP2 interacts with the nuclear protein to assemble the virion. It also acts as a viral fusion protein under acidic conditions. Other proteins found in the cells include the most abundant nucleocapsid protein and the first protein expressed in infected cells.