Japanese Create “See-Through” Frogs

These funny Japanese have done it again! By combining the two recessive genes that make the frog pale, they created a nearly transparent frog. Unfortunately for frogs there are many advantages to testing perspective creatures. For example, "You can see how the organs grow and how they can develop and develop through the skin," says Mr. Masayuki Sumida, a professor at the Amphibian Institute of Hiroshima University doing. "You can observe the same frog organs without dissection, and researchers can also observe how toxins affect bones, liver, and other organs at a lower cost."

You can even observe eggs through the frog skin without having to dissect the animal. Basically, this is an advantageous situation for frogs, but now you can extend your life through various diseases.

We like to call it "Organ Bag" developed by mutant Rena japonica, also known as transparent frog or Japanese brown frog. Obviously, this is the first transparent quadruped in history, so it is clear that Sumida is competing for "getting a patent there". (Rough translation)

We have succeeded in making transparent frogs, usually with vermiculite or natural color mutants of Rana japonica with a brown back; this coloration is through the skin without dissection, body, blood vessels and eggs It is allowed to be observed. We artificially inseminated frogs through two recessive color mutants (black eyes and gray eyes), and the F2 offspring creates a frog whose skin is translucent throughout their lifecycle. Three dermal pigment cells of xanthomonas, iris cells, and melanocytes were seen on the skin of wild-type frogs, but pigment cells were hardly seen on the frog's skin. Translucent skin allows observation of the growth of animal organs and the formation and progression of cancer, which can be monitored throughout life without dissecting

The first perspective frog made by breeding: explanation, genetic model and dermal chromatographic structure

These funny Japanese have done it again! By combining the two recessive genes that make the frog pale, they created a nearly transparent frog. Unfortunately for frogs there are many advantages to testing perspective creatures. For example, "You can see how the organs grow and how they can develop and develop through the skin," says Mr. Masayuki Sumida, a professor at the Amphibian Institute of Hiroshima University doing. "You can observe the same frog organs throughout your life without dissecting, and researchers can also observe how toxins affect bones, liver, and other organs at a lower cost . "

The genetic engineering of the perspective frog is a method that can be used to create a transparent fluorescent frog. In the near future, we plan to create a transparent and fluorescent frog by injecting a fluorescent GFP tagged gene into a frog. And it enables frogs to fluoresce and show expression of marker genes 18. It can be used for a variety of purposes, for example to indicate when cancer will begin. Perspective frogs can also be used as experimental model animals in various fields such as medicine, veterinary medicine, biology and education. Frogs can also be viewed as commercial production and marketing applications for ornamental pets, with the nickname "skelepyeon" and combining the words "perspective" and "frog".

The first perspective frog made by breeding: explanation, genetic model and dermal chromatographic structure