Instruments for automated peptide synthesis.

This chapter describes existing equipment for solid phase peptide synthesis (SPPS). Currently, the two most common designs are handled differently in liquid. The first is to use valves and valve blocks to distribute the reagents, the second is to use the robot platform. The former can use injection, 180 ° rotational vibration or vortex, the latter usually using vortex. Valve-based equipment is usually single channel (one peptide at a time) but it can be extended to allow parallel synthesis of up to 12 or 24 peptides, but at the expense of complexity. The valve system is usually operated with inert gas. The X - Y robot platform is also ideal for mass synthesis of up to 192 peptides, and even peptide libraries. However, although not very common, the robot platform is also suitable for single channel operation and can be used for operation under inert gas. There are several single-channel synthesizers for UV feedback monitoring of Fmoc rejection that can be used in some applications. Significantly, the single-channel synthesizer can be equipped with rapid and accurate microwave heating to speed up the synthesis and to overcome the difficulties of synthesis. Synthesizers of various designs are on the market. The choice of peptide synthesizer depends on the intended use, such as the type of chemical, the size and amount of peptide required.

Activo-P11 Peptide Synthesizer is an easy-to-use, affordable device for synthesizing high-quality peptides. Activo-P11 is the only synthesizer available for automatic reactor heating and UV monitoring. These valuable synthesis tools allow chemists to synthesize longer and harder peptides and obtain more synthesis information on these peptides. For example, the antimicrobial peptide gomersin has been successfully synthesized using conventional heating.

APPTec manufactures automatic peptide synthesizers from research (several milligrams) to pilots and various production scale production (several kilograms). Our peptide equipment includes Endeavor 90, a benchtop automatic peptide synthesizer with a long history of reliable service, market leader peptide library synthesizer Apex 396, and the first split combination peptide synthesizer Titan 357 included. Our state-of-the-art equipment includes the Focus XC series automatic peptide synthesizer and Apex 396HT for high-throughput synthetic peptide libraries in a convenient 96-well titration plate.

Biotage is the sole manufacturer of room temperature peptide synthesizer and microwave peptide synthesizer with entry level and high throughput configuration. We prepare manual, semi-automatic and fully automated peptide synthesis system according to customer's needs. Whether we need a system that can generate a single peptide or multiple peptides at the same time, we can provide equipment that meets your requirements. Since 1993, CSBio is a leader in automated peptide synthesis. The company offers a variety of peptide synthesizers for research, process development, and large-scale manufacturing. Our synthesizers are available in reactors of various sizes from 10 mL to 1000 L and can be found in hundreds of peptide manufacturing laboratories around the world.

The Protein Technologies peptide synthesizer is designed to cover a synthesis scale of 0.001 to 200 mmol. We offer a range of peptide synthesizers to meet your need. Whether your chemical composition is a combination, small organic molecule, peptide (Fmoc or t-Boc), peptidomimetic or DNA, Protein Technologies has a peptide synthesizer for you.