Influenza Virus

Fine epitope mapping of anti-H5 2A - scFvFc antibody. A. Flow cytometric analysis showed the immunoreactivity of the monoclonal HA1 - M mutant on the surface of yeast. Single point mutations that eliminate yeast surface binding to H5 2AscFvFc were eliminated and localized in different regions of HA1. B. Schematic representation of the epitope recognized by the HA antigen on the yeast surface by anti-H5 2AFc. Amino acid positions are indicated by the H 5 number. Linear epitopes recognized by 2AFc (amino acids 206-211) were colored red.

The systematic diagram is a graphical representation of the geographical relationship between species. They show that human influenza virus is minimally affected by geographical differences. However, swine and bird flu seems geographically dependent. All three groups (birds, pigs, and humans) showed chronological differences. Since human influenza virus remains only in the human body, it does not spread to other species. Certain strains and sublines of the virus may emerge and become more common in certain places. For example, the occurrence of many human influenza has started in Southeast Asia.

In February 2004, avian influenza virus was detected from birds in Vietnam, concern about the emergence of new variants is increasing. Where avian influenza virus is combined with human influenza virus (in birds or humans), it is feared that the new subtypes created will be highly contagious and very deadly for humans. This subtype can cause a worldwide influenza epidemic similar to the Spanish flu or a high mortality epidemic such as the Asian cold or Hong Kong cold. In October 2005, a case of avian influenza (a deadly H5N1 strain) was discovered in Turkey. Markos Kyprianou of the European Health Committee said, "The virus found in Turkey was confirmed to be avian influenza H5N1 virus, which is directly related to viruses found in Russia, Mongolia and China." Influenza cases The possibility of virus is detected also in Croatia, Bulgaria, UK.