Importance of Glycophorin A Protein Found in Red Blood Cells

Each dimer is an alpha helix containing 40 amino acids. According to RCSB protein database, homodimer is asymmetric as shown, GpA protein has about 400 alpha-helix span to localize the interface devoid of hydrogen bond in the monomer. The placement of the interface provides a physical basis for the interaction between the two helices. It was observed that the two glycines contribute to the skeleton-skeletal contact of the helix. The sequence between the ends of the dimers is embedded in the bilayer, as they are predominantly hydrophobic residues.

Sickle cell disease (SCD) is a group of hereditary erythroid diseases. If you suffer from SCD, your hemoglobin will have problems. Hemoglobin is a protein in erythrocytes that carries oxygen into the body. Together with SCD, hemoglobin forms a hard rod in red blood cells. This changes the shape of red blood cells. The cells should be disk shaped, but this turns them into a crescent shape or a sickle shape. Sickle cell is inflexible and does not easily deform. Many of them burst when you pass through your blood vessels. Sickle cell usually lasts only 10 to 20 days and does not last for 90 to 120 days as usual. Your body may not be able to make enough new cells to replace your lost cells. Therefore, you may not have enough red blood cells. This is a condition called anemia, it can make you feel tired

Sickle cell disease is a group of hereditary blood diseases that affect red blood cells in the blood. Red blood cells contain a protein called hemoglobin that carries oxygen in the body. Although hemoglobin is flexible in the normal disk shape, in this case, the red blood cells due to abnormal hemoglobin gene is formed like a "sickle cell", called thus sickle cell disease. Approximately 5% of the world population holds genes for hemoglobin disease, mainly sickle cell disease and thalassemia. About 300,000 babies worldwide are estimated to be born in a severe form of sickle cell anemia, the most low-income countries and middle-income countries, it has occurred especially in Africa, Arabia, in India.