Identification of Cuminoids with Anticancer Activity

Many epidemiological studies indicate that high vegetable and fruit diets are associated with a reduction in the risk of most cancers [1, 2]. Herbs and spices have been used for treating various diseases since ancient times. They have been used to treat the respiratory tract, digestive tract, rheumatism and inflammatory diseases. Beneficial effects on dietary phytochemicals such as curcumin (from turmeric), allicin (from garlic), resveratrol (from grapes and peanuts) and inflammation and cancer only increase the importance of dietary management of this chronic disease It is [3]].

Several plant anticancer and anti-inflammatory compounds are currently identified. Scientific experiments are being conducted on the anticancer action of plants and their ingredients. Herbs are the basis for the treatment and treatment of various diseases and physiological conditions such as Ayurveda, Unani, Siddha. However, no systematic study has been conducted to evaluate the efficacy and safety of plant-derived preparations. No attempt has been made to isolate and identify the active ingredients involved in these actions.

Saxena et al. Transplanted chalcone derivatives to the estradiol skeleton, some of which showed potent anticancer activity against specific human cancer cell lines. Effective activity against estrogen receptor positive and hormone dependent human breast cancer cell line MCF - 7 Red blood cells were also used as a model system to evaluate osmotic lysis of active anticancer derivatives. The chalcone derivatives showing cytotoxicity against cancer cell lines were thought to be non-toxic to normal cells because they do not affect the brittleness of erythrocytes, but also trimethoxychalcone having various fluorination patterns evaluated. Nitric oxide produced by its derivatives. One of the compounds, 2,4,6-trimethoxy-20-trifluoromethyl chalcone, inhibited the production of NO and prostaglandin E 2 in lipopolysaccharide stimulated RAW 264.7 macrophages.