History of Prions

Prion streptomycin virus Abnormally folded proteins cause neurological symptoms and cause death. This disease can spread to all kinds, but there is a species barrier related to it. Kuru was first discovered in a previous tribe in Papua, New Guinea. Later it was discovered that this was a ritual cannibal act that took place in this tribe. For centuries scientists have studied the disease, but I discovered that the disease is neither caused by the virus nor caused by the infection.

Prion disease is a group of neurodegenerative diseases caused by prions, "protein infectious particles". For some background, the first thing to see is the introduction of prions. Prion diseases are caused by prion proteins in misfolded form, also known as PrP. In addition to humans, these diseases affect many different mammals - for example, sheep have scrapie, cows have mad cow disease, and deer has chronic wasting disease. Human-type prion diseases are usually caused by Creutzfeldt-Jakob disease (CJD), fatal familial insomnia (FFI), Geltmann-Straussler-Scheinker syndrome (GSS), rickets disease and variable protease susceptible prion diseases (VPSPr) Since all of these diseases are caused by slightly different versions of the same protein, we call them all prion diseases.

Infectious protein acting like virus but without DNA. Prion is an infection because misfolded versions of prion protein can misfold fold the normal form of prion protein to spread the disease. Incorrectly folded proteins will not function correctly. The normal prion protein spreads throughout the life-kingdom and plays an important role. Proteins are composed of amino acid chains and are large molecules with various functions indispensable for the life of organisms. Depending on the composition of the protein, the protein acts as an antibody in the immune system, or it helps signal transduction between cells and internal organs in the body. DNA is the genetic code of the cell, and it is a design drawing of all the proteins in the cell.