Heterocyclic Chemistry: The Knorr Synthesis of Pyrroles

Synthesis of pyrrole 2,4-diethoxycarbonyl-3,5-dimethylpyrrole by double condensation reaction using α-amino ketone acetoacetamidoacetate. When the product was analyzed by 1 H NMR, 13 C NMR, mass spectrum and IR spectrum, a positive result was obtained. Introduction Because of its heteroaromatic character, pyrrole has always been a very interesting molecule. A lone pair of electrons on nitrogen is delocalized within the ionic ring, resulting in an electron rich heterocycle.

Heterocyclic chemistry is a chemical field that specifically addresses the synthesis, properties and uses of heterocycles. A heterocyclic compound is an organic compound containing a ring structure containing an atom other than carbon as part of the ring, for example, sulfur, oxygen or nitrogen. They can be simple aromatic rings or nonaromatic rings. Every year hundreds of thousands of new organic compounds are prepared, many of which enter pharmacological screening to determine if they have useful biological activity. Molecular graphics and computational chemistry technology provide a new chemical structure that brings new drugs

Synthesis of pyrrole 2,4-diethoxycarbonyl-3,5-dimethylpyrrole by double condensation reaction using α-amino ketone acetoacetamidoacetate. When the product was analyzed by 1 H NMR, 13 C NMR, mass spectrum and IR spectrum, a positive result was obtained. Introduction Because of its heteroaromatic character, pyrrole has always been a very interesting molecule. A lone pair of electrons on nitrogen is delocalized within the ionic ring, resulting in an electron rich heterocycle.

Thiosemicarbazones are important intermediates for organic synthesis, heterocyclic drugs and agricultural chemicals have a wide range of applications in synthesis, and some metal derivatives are of great application value. Literature review reported that thiosemicarbazide drew attention of researchers. Different synthesis method using 2-step thiosemicarbazide as a raw material, usually hydrazine hydrate and carbon disulfide