Hemostasis

Haemostasis is a normal physiological reaction of the body to prevention and hemostasis / hemorrhage. It causes any disturbance of vascular rupture. In general, it helps to ensure blood flow and vessel integrity. Abnormal hemostasis can cause bleeding (bleeding) or thrombosis (thrombosis)

Plasma coagulation including interaction between multiple factors and inhibitors (secondary hemostasis)

When blood vessels rupture, the main task is to stop bleeding. The main participants in the blood are platelets and fibrinogen, which act as platelet plugs.

Figure 1: Formation of thrombus (Source: Introduction l'étudedel'hestmostaseetdela tombose - B. Boneu, J - P. Cazenave - 1997) Bleeding at the site of vascular injury is stopped by the formation of extravascular thrombi. The injury causes transient vasoconstriction of small blood vessels, thereby reducing blood flow. Platelets adhere to subendothelial tissue at the site of injury, and eventually they aggregate together. The onset of clotting leads to the formation of fibrin, which stabilizes the clot and helps stop bleeding.

After the first step, thrombus formation prevents further bleeding. This process involves a series of chemical reactions involving various plasma components. To date, 10 major clotting factors are known to be involved in this process. These complex interactions result in the conversion of fibrin fibrillin. As part of the wound healing process, fibrinolysis dissolves the thrombus

Diagnosis of coagulopathy by use of clinical examination, coagulation test, analytical test (especially on various elements of coagulation) of the blood clotting process, or the blood cell count of leukocytes per cubic millimeter of blood (amount and quantity of hemoglobin), red blood cells and platelet)

Some of these tests can also be used to measure the effect of anticoagulant therapy used to treat or alleviate the risk of thrombosis. Diagnostica Stago develops and designs laboratory equipment and various test methods to measure and better understand coagulation / hemostasis

Haemostasis can be accomplished in a variety of other ways when the body naturally (or does not require help) during surgery or medical procedures. When the body is under shock or stress, hemostasis is more difficult to achieve. Natural hemostasis is most needed but in many emergencies it is important for survival to have other ways to achieve this goal. Without the ability to stimulate hemostasis, the risk of bleeding is high. During surgery, the types of hemostasis listed below can be used to control bleeding while avoiding and reducing the risk of tissue damage. Hemostasis can be achieved by chemical reagents and mechanical or physical reagents. Which type of hemostasis to use is determined on a case by case basis

Haemostasis diagnosis is a device used to determine haemostatic problems that cause excessive bleeding. Hemostasis is defined as the prevention or delay of blood flow to damaged blood vessels. During hemostasis, blood changes from liquid to gel. Hemostasis is maintained in the body by three mechanisms: blood coagulation, platelet embolism and vasoconstriction. By identifying a hemostatic disorder in a patient, hemostasis diagnosis can help predict the cause of bleeding during surgery. We perform various kinds of tests such as prothrombin test, activation coagulation time, platelet function, other coagulation tests, etc. to judge hemostasis

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